A simplified evaluation of the response to treatment in the second and subsequent lines of treatment
| Response to . | . |
|---|---|
| Second-line TKI | |
| In case of failure, toxicity, or intolerance | Same as response to first-line |
| In case of early switch (6 and 12 mo) for nonoptimal response | Same as response to first-line |
| In case of late switch for nonoptimal response | Personalized evaluation |
| Third- or fourth-line TKI | Personalized evaluation |
| Response to . | . |
|---|---|
| Second-line TKI | |
| In case of failure, toxicity, or intolerance | Same as response to first-line |
| In case of early switch (6 and 12 mo) for nonoptimal response | Same as response to first-line |
| In case of late switch for nonoptimal response | Personalized evaluation |
| Third- or fourth-line TKI | Personalized evaluation |