Baseline microvascular and integrative characteristics of nontraining and training SCD patients
| Variables . | All (n = 32) . | Nontraining patients (n = 17) . | Training patients (n = 15) . | P . |
|---|---|---|---|---|
| Microvascular characteristics | ||||
| Morphological characteristics | ||||
| CP, µm | 37.1 (9.6) | 39.0 (11.5) | 34.9 (6.8) | .289 |
| CSA, µm2 | 63.8 [39.0; 77.0] | 66.8 [39.3; 80.9] | 53.6 [38.8; 66.4] | .299 |
| COD, µm | 6.1 [4.8; 6.8] | 6.3 [4.9; 7.0] | 5.4 [4. 8; 6.4] | .299 |
| COD <5 µm, % | 26.7 [16.0; 62.6] | 20.5 [15.9; 64.4] | 48.2 [16.0; 61.3] | .664 |
| 5 < COD <10 µm, % | 61.0 [36.0; 77.0] | 72.2 [33.3; 76.5] | 50.0 [37.6; 79.3] | .985 |
| COD >10 µm, % | 1.5 [0.0; 4.3] | 2.3 [0.0; 5.5] | 1.1 [0.0; 2.8] | .395 |
| CapTor, A.U. | 2.14 (0.12) | 2.12 (0.10) | 2.16 (0.13) | .445 |
| Quantitative characteristics | ||||
| CD, cap/mm2 | 195 (32) | 193 (31) | 198 (34) | .611 |
| CAF, cap/fiber | ||||
| All fibers (mean) | 2.4 [2.1; 2.8] | 2.3 [2.0; 2.7] | 2.5 [2.2; 2.8] | .396 |
| Type I fibers | 2.8 [2.4; 3.3] | 2.8 [2.4; 3.1] | 2.8 [2.6; 3.3] | .748 |
| Type IIa fibers | 2.2 [1.9; 2.5] | 2.1 [1.9; 2.3] | 2.3 [2.1; 2.5] | .089 |
| Type IIx fibers | 1.5 [1.8; 1. 7] | 1.3 [1.2; 1.5] | 1.5 [1.3; 1.9] | .443 |
| Functional indexes | ||||
| LC, µm | 27.7 (10.7) | 28.5 (12.4) | 26.8 (8.7) | .653 |
| LC/PF, % | ||||
| All fibers (mean) | 11.2 (3.3) | 11.6 (3.9) | 10.9 (2.6) | .579 |
| Type I fibers | 13.4 (3.3) | 13.8 (3.7) | 12.9 (2.8) | .434 |
| Type IIa fibers | 10.3 (3.2) | 10.6 (3.5) | 10.1 (2.9) | .660 |
| Type IIx fibers | 6.5 [4.7; 8.2] | 5.5 [4.0; 8.2] | 7.1 [6.1; 8.1] | .292 |
| CD × CSA, µm2/mm2 | 14 400 (6622) | 15 146 (7601) | 13 554 (5444) | .506 |
| CD × CSA × Hb, A.U. | 1.34 (0.78) | 1.43 (0.83) | 1.25 (0.75) | .520 |
| Integrative data | ||||
| At LT1 | ||||
| Power output, W | 40.0 [30.0; 45.0] | 35.0 [30.0; 43.8] | 40.0 [30.0; 45.0] | .914 |
| O2, L/min | 0.64 [0.58; 0.82] | 0.67 [0.59; 0.78] | 0.62 [0.58; 0.82] | .638 |
| TSI, % | 66.0 [63.1; 67.9] | 65.9 [61.1; 67.5] | 66.0 [64.4; 68.0] | .539 |
| At 40W (women) and 60W (men) | ||||
| O2, L/min | 0.79 (0.19) | 0.82 (0.19) | 0.77 (0.19) | .461 |
| HR, min | 135 (17) | 137 (18) | 131 (15) | .331 |
| [lactate]b, mmol/L | 2.7 (0.7) | 2.7 (0.7) | 2.6 (0.8) | .857 |
| RPE, A.U. | 3.0 [1.5; 5.5] | 3.0 [1.3; 4.0] | 2.5 [1.8; 5.8] | 1.000 |
| Variables . | All (n = 32) . | Nontraining patients (n = 17) . | Training patients (n = 15) . | P . |
|---|---|---|---|---|
| Microvascular characteristics | ||||
| Morphological characteristics | ||||
| CP, µm | 37.1 (9.6) | 39.0 (11.5) | 34.9 (6.8) | .289 |
| CSA, µm2 | 63.8 [39.0; 77.0] | 66.8 [39.3; 80.9] | 53.6 [38.8; 66.4] | .299 |
| COD, µm | 6.1 [4.8; 6.8] | 6.3 [4.9; 7.0] | 5.4 [4. 8; 6.4] | .299 |
| COD <5 µm, % | 26.7 [16.0; 62.6] | 20.5 [15.9; 64.4] | 48.2 [16.0; 61.3] | .664 |
| 5 < COD <10 µm, % | 61.0 [36.0; 77.0] | 72.2 [33.3; 76.5] | 50.0 [37.6; 79.3] | .985 |
| COD >10 µm, % | 1.5 [0.0; 4.3] | 2.3 [0.0; 5.5] | 1.1 [0.0; 2.8] | .395 |
| CapTor, A.U. | 2.14 (0.12) | 2.12 (0.10) | 2.16 (0.13) | .445 |
| Quantitative characteristics | ||||
| CD, cap/mm2 | 195 (32) | 193 (31) | 198 (34) | .611 |
| CAF, cap/fiber | ||||
| All fibers (mean) | 2.4 [2.1; 2.8] | 2.3 [2.0; 2.7] | 2.5 [2.2; 2.8] | .396 |
| Type I fibers | 2.8 [2.4; 3.3] | 2.8 [2.4; 3.1] | 2.8 [2.6; 3.3] | .748 |
| Type IIa fibers | 2.2 [1.9; 2.5] | 2.1 [1.9; 2.3] | 2.3 [2.1; 2.5] | .089 |
| Type IIx fibers | 1.5 [1.8; 1. 7] | 1.3 [1.2; 1.5] | 1.5 [1.3; 1.9] | .443 |
| Functional indexes | ||||
| LC, µm | 27.7 (10.7) | 28.5 (12.4) | 26.8 (8.7) | .653 |
| LC/PF, % | ||||
| All fibers (mean) | 11.2 (3.3) | 11.6 (3.9) | 10.9 (2.6) | .579 |
| Type I fibers | 13.4 (3.3) | 13.8 (3.7) | 12.9 (2.8) | .434 |
| Type IIa fibers | 10.3 (3.2) | 10.6 (3.5) | 10.1 (2.9) | .660 |
| Type IIx fibers | 6.5 [4.7; 8.2] | 5.5 [4.0; 8.2] | 7.1 [6.1; 8.1] | .292 |
| CD × CSA, µm2/mm2 | 14 400 (6622) | 15 146 (7601) | 13 554 (5444) | .506 |
| CD × CSA × Hb, A.U. | 1.34 (0.78) | 1.43 (0.83) | 1.25 (0.75) | .520 |
| Integrative data | ||||
| At LT1 | ||||
| Power output, W | 40.0 [30.0; 45.0] | 35.0 [30.0; 43.8] | 40.0 [30.0; 45.0] | .914 |
| O2, L/min | 0.64 [0.58; 0.82] | 0.67 [0.59; 0.78] | 0.62 [0.58; 0.82] | .638 |
| TSI, % | 66.0 [63.1; 67.9] | 65.9 [61.1; 67.5] | 66.0 [64.4; 68.0] | .539 |
| At 40W (women) and 60W (men) | ||||
| O2, L/min | 0.79 (0.19) | 0.82 (0.19) | 0.77 (0.19) | .461 |
| HR, min | 135 (17) | 137 (18) | 131 (15) | .331 |
| [lactate]b, mmol/L | 2.7 (0.7) | 2.7 (0.7) | 2.6 (0.8) | .857 |
| RPE, A.U. | 3.0 [1.5; 5.5] | 3.0 [1.3; 4.0] | 2.5 [1.8; 5.8] | 1.000 |
Results are expressed as mean (SD) or median [IQR]. P represents the difference between nontraining and training patients.