Multivariate model incorporating Mayo disease stage, presenting dFLC, and 6-month absolute dFLC values
| . | Hazard ratio . | P . | 95% confidence interval . |
|---|---|---|---|
| OS | |||
| Mayo disease stage | |||
| 1 | 2.05 | .06 | 0.96-4.34 |
| 2 | 3.7 | .01 | 1.74-7.86 |
| 3 | 6.49 | <.001 | 2.96-14.21 |
| Presenting dFLC < 180 mg/L | 1.3 | .04 | 1.01-1.68 |
| ECOG score | |||
| 1 | 1.25 | .29 | 0.83-1.9 |
| 2 | 2.12 | <.001 | 1.39-3.22 |
| 3 | 2.3 | .004 | 1.3-4.08 |
| TNT | |||
| Mayo disease stage | |||
| 1 | 1.01 | .96 | 0.70-1.47 |
| 2 | 0.84 | .40 | 0.56-1.26 |
| 3 | 0.91 | .73 | 0.52-1.58 |
| Presenting dFLC < 180 mg/L | 0.94 | .70 | 0.71-1.26 |
| 6 mo dFLC, mg/L | |||
| <10 | Reference | ||
| 10-20 | 2.76 | <.001 | 1.72-4.43 |
| 20-30 | 2.78 | <.001 | 1.74-4.46 |
| 30-40 | 3.27 | <.001 | 1.82-5.87 |
| 40-50 | 3.81 | <.001 | 2.32-6.28 |
| >50 |
| . | Hazard ratio . | P . | 95% confidence interval . |
|---|---|---|---|
| OS | |||
| Mayo disease stage | |||
| 1 | 2.05 | .06 | 0.96-4.34 |
| 2 | 3.7 | .01 | 1.74-7.86 |
| 3 | 6.49 | <.001 | 2.96-14.21 |
| Presenting dFLC < 180 mg/L | 1.3 | .04 | 1.01-1.68 |
| ECOG score | |||
| 1 | 1.25 | .29 | 0.83-1.9 |
| 2 | 2.12 | <.001 | 1.39-3.22 |
| 3 | 2.3 | .004 | 1.3-4.08 |
| TNT | |||
| Mayo disease stage | |||
| 1 | 1.01 | .96 | 0.70-1.47 |
| 2 | 0.84 | .40 | 0.56-1.26 |
| 3 | 0.91 | .73 | 0.52-1.58 |
| Presenting dFLC < 180 mg/L | 0.94 | .70 | 0.71-1.26 |
| 6 mo dFLC, mg/L | |||
| <10 | Reference | ||
| 10-20 | 2.76 | <.001 | 1.72-4.43 |
| 20-30 | 2.78 | <.001 | 1.74-4.46 |
| 30-40 | 3.27 | <.001 | 1.82-5.87 |
| 40-50 | 3.81 | <.001 | 2.32-6.28 |
| >50 |
ECOG, Eastern Cooperative Oncology Group.