Dinucleotide analysis of N-nucleotides from adult NPM1 mutations
| Dinucleotide . | No. obs . | No. exp . | Obs/exp ratio . | P . | Significant at P = .05 . |
|---|---|---|---|---|---|
| RR* | |||||
| GG | 24 | 17.01 | 1.41 | .065 | No |
| AA | 19 | 16.66 | 1.14 | .318 | No |
| GA | 25 | 16.84 | 1.48 | .032 | Yes |
| AG | 28 | 16.84 | 1.66 | .006 | Yes |
| YY* | |||||
| CC | 54 | 55.69 | 0.97 | .612 | No |
| TT | 47 | 31.26 | 1.50 | .004 | Yes |
| CT | 42 | 41.73 | 1.01 | .497 | No |
| TC | 44 | 41.73 | 1.05 | .370 | No |
| RY† | |||||
| GC | 30 | 30.78 | 0.97 | .493 | No |
| GT | 12 | 23.06 | 0.52 | .008 | Yes |
| AT | 14 | 22.82 | 0.61 | .034 | Yes |
| AC | 15 | 30.46 | 0.49 | .001 | Yes |
| YR† | |||||
| CG | 32 | 30.78 | 1.04 | .638 | No |
| CA | 28 | 30.46 | 0.92 | .378 | No |
| TG | 19 | 23.06 | 0.82 | .228 | No |
| TA | 19 | 22.82 | 0.83 | .258 | No |
| Dinucleotide . | No. obs . | No. exp . | Obs/exp ratio . | P . | Significant at P = .05 . |
|---|---|---|---|---|---|
| RR* | |||||
| GG | 24 | 17.01 | 1.41 | .065 | No |
| AA | 19 | 16.66 | 1.14 | .318 | No |
| GA | 25 | 16.84 | 1.48 | .032 | Yes |
| AG | 28 | 16.84 | 1.66 | .006 | Yes |
| YY* | |||||
| CC | 54 | 55.69 | 0.97 | .612 | No |
| TT | 47 | 31.26 | 1.50 | .004 | Yes |
| CT | 42 | 41.73 | 1.01 | .497 | No |
| TC | 44 | 41.73 | 1.05 | .370 | No |
| RY† | |||||
| GC | 30 | 30.78 | 0.97 | .493 | No |
| GT | 12 | 23.06 | 0.52 | .008 | Yes |
| AT | 14 | 22.82 | 0.61 | .034 | Yes |
| AC | 15 | 30.46 | 0.49 | .001 | Yes |
| YR† | |||||
| CG | 32 | 30.78 | 1.04 | .638 | No |
| CA | 28 | 30.46 | 0.92 | .378 | No |
| TG | 19 | 23.06 | 0.82 | .228 | No |
| TA | 19 | 22.82 | 0.83 | .258 | No |
Calculated using frequencies of individual nucleotides G = 0.194, A = 0.192, T = 0.263, and C = 0.351.
For the RR and YY dinucleotides, the P value reflects the cumulative binomial probability of the observed value exceeding or equalling the expected value.
For RY and YR dinucleotides, the P value is for observed values less than or equal to the expected value.