Table 2.

Pediatric NPM1 Mutation Sequences

TypeNucleotide sequence of NPM1 mutationsTranslationOccurrence
WT gat​ctc​tgg​cag​tgg​agg​aag​tct​ctt​taa DLWQWRKSL NA 
 gatctct ATCT ggc​agt​gga​gga​agt​ctc​ttt​aag​aaa​ata​g DLYLAVEEVSLRK 1 
 gatctctg CAGG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCRAVEEVSLRK 1 
B gatctctg CATG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCMAVEEVSLRK 18 
 gatctctg CCGG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCRAVEEVSLRK 3 
D gatctctg CCTG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCLAVEEVSLRK 8 
 gatctctg CGGA gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCGAVEEVSLRK 1 
 gatctctg CTTG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCLAVEEVSLRK 1 
 gatctctg TACG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCTAVEEVSLRK 1 
 gatctctg TATG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCMAVEEVSLRK 1 
 gatctctg TCAG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCQAVEEVSLRK 1 
 gatctctg TCGG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCRAVEEVSLRK 1 
A gatctctg TCTG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCLAVEEVSLRK 43 
 gatctctg TGCC gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCAAVEEVSLRK 1 
 gatctctg TGTG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCVAVEEVSLRK 2 
 gatctctggc TCCGATTTGC gga​agt​ctc​ttt​aag​aaa​ata​g DLWLRFAEVSLRK 1 
 gatctctggca AGATCTCAGCAAG gtctctttaagaaaatag DLWQDLSKVSLRK 1 
 gatctctggcag CGGA tgg​agg​aag​tct​ctt​taa​gaa​aat​ag DLWQRMEEVSLRK 1 
 gatctctggcag CGGATGGCC gaa​gtc​tct​tta​aga​aaa​tag DLWQRMAEVSLRK 1 
 gatctctggcag CGGATTCC gga​agt​ctc​ttt​aag​aaa​ata​g DLWQRIPEVSLRK 2 
 gatctctggcag CGTTC gga​gga​agt​ctc​ttt​aag​aaa​ata​g DLWQRSEEVSLRK 1 
 gatctctggcagt ATCTGGGGGCCC ggaggaagtctctttaa DLWQYLGARRKSL 1 
 gatctctggcagt CCCTCGCCC aag​tct​ctt​taa​gaa​aat​ag DLWQSLAQVSLRK 1 
 gatctctggcagt CCTTTTCCC aag​tct​ctt​taa​gaa​aat​ag DLWQSFSQVSLRK 1 
 gatctctggcagt GCTTCGCCA aag​tct​ctt​taa​gaa​aat​ag DLWQCFAKVSLRK 1 
 gatctctggcagt GTTTTTCAA aag​tct​ctt​taa​gaa​aat​ag DLWQCFSKVSLRK 1 
 gatctctggcagt TACTTTCCC aag​tct​ctt​taa​gaa​aat​ag DLWQLLSQVSLRK 1 
 gatctctggcagt TATTTTCCC aag​tct​ctt​taa​gaa​aat​ag DLWQLFSQVSLRK 1 
 gatctctggcagtgga CCCT gga​agt​ctc​ttt​aag​aaa​ata​g DLWQWTLEVSLRK 1 
 gatctctggcagtgga TGGA gga​agt​ctc​ttt​aag​aaa​ata​g DLWQWMEEVSLRK 1 
 gatTtTtgg​cagGgga​gga​agtTtTttt​aag​aaa​ata​g DFWQGRKFF 1 
 gat​ctc​tgg​cagGgga​gga​agCctc​ttt​aag​aaa​ata​g DLWQGRKPL 1 
TypeNucleotide sequence of NPM1 mutationsTranslationOccurrence
WT gat​ctc​tgg​cag​tgg​agg​aag​tct​ctt​taa DLWQWRKSL NA 
 gatctct ATCT ggc​agt​gga​gga​agt​ctc​ttt​aag​aaa​ata​g DLYLAVEEVSLRK 1 
 gatctctg CAGG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCRAVEEVSLRK 1 
B gatctctg CATG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCMAVEEVSLRK 18 
 gatctctg CCGG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCRAVEEVSLRK 3 
D gatctctg CCTG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCLAVEEVSLRK 8 
 gatctctg CGGA gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCGAVEEVSLRK 1 
 gatctctg CTTG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCLAVEEVSLRK 1 
 gatctctg TACG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCTAVEEVSLRK 1 
 gatctctg TATG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCMAVEEVSLRK 1 
 gatctctg TCAG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCQAVEEVSLRK 1 
 gatctctg TCGG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCRAVEEVSLRK 1 
A gatctctg TCTG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCLAVEEVSLRK 43 
 gatctctg TGCC gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCAAVEEVSLRK 1 
 gatctctg TGTG gca​gtg​gag​gaa​gtc​tct​tta​aga​aaa​tag DLCVAVEEVSLRK 2 
 gatctctggc TCCGATTTGC gga​agt​ctc​ttt​aag​aaa​ata​g DLWLRFAEVSLRK 1 
 gatctctggca AGATCTCAGCAAG gtctctttaagaaaatag DLWQDLSKVSLRK 1 
 gatctctggcag CGGA tgg​agg​aag​tct​ctt​taa​gaa​aat​ag DLWQRMEEVSLRK 1 
 gatctctggcag CGGATGGCC gaa​gtc​tct​tta​aga​aaa​tag DLWQRMAEVSLRK 1 
 gatctctggcag CGGATTCC gga​agt​ctc​ttt​aag​aaa​ata​g DLWQRIPEVSLRK 2 
 gatctctggcag CGTTC gga​gga​agt​ctc​ttt​aag​aaa​ata​g DLWQRSEEVSLRK 1 
 gatctctggcagt ATCTGGGGGCCC ggaggaagtctctttaa DLWQYLGARRKSL 1 
 gatctctggcagt CCCTCGCCC aag​tct​ctt​taa​gaa​aat​ag DLWQSLAQVSLRK 1 
 gatctctggcagt CCTTTTCCC aag​tct​ctt​taa​gaa​aat​ag DLWQSFSQVSLRK 1 
 gatctctggcagt GCTTCGCCA aag​tct​ctt​taa​gaa​aat​ag DLWQCFAKVSLRK 1 
 gatctctggcagt GTTTTTCAA aag​tct​ctt​taa​gaa​aat​ag DLWQCFSKVSLRK 1 
 gatctctggcagt TACTTTCCC aag​tct​ctt​taa​gaa​aat​ag DLWQLLSQVSLRK 1 
 gatctctggcagt TATTTTCCC aag​tct​ctt​taa​gaa​aat​ag DLWQLFSQVSLRK 1 
 gatctctggcagtgga CCCT gga​agt​ctc​ttt​aag​aaa​ata​g DLWQWTLEVSLRK 1 
 gatctctggcagtgga TGGA gga​agt​ctc​ttt​aag​aaa​ata​g DLWQWMEEVSLRK 1 
 gatTtTtgg​cagGgga​gga​agtTtTttt​aag​aaa​ata​g DFWQGRKFF 1 
 gat​ctc​tgg​cagGgga​gga​agCctc​ttt​aag​aaa​ata​g DLWQGRKPL 1 

Inserted bases are shown in bold capital letters in the second column. The 4 conserved hydrophobic positions of the nuclear export signal are in bold-face type in the third column. The first base shown is c.856 from the coding reference sequence.

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