Adult NPM1 mutation sequences
| Type . | Nucleotide sequence of NPM1 mutations . | Translation . | Occurrence . |
|---|---|---|---|
| WT | gatctctggcagtggaggaagtctctttaa | DLWQWRKSL | NA |
| gatct ATGC ctggcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 1 | |
| gatct TTGC ctggcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 1 | |
| gatct TTGTCTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 1 | |
| gatctc ACAA tggcagtggaggaagtctctttaagaaaatag | DLTMAVEEVSLRK | 1 | |
| gatctc ATTAA ggcagtggaggaagtctctttaagaaaatag | DLIKAVEEVSLRK | 1 | |
| gatctc ATTC tggcagtggaggaagtctctttaagaaaatag | DLILAVEEVSLRK | 1 | |
| gatctc CGCA tggcagtggaggaagtctctttaagaaaatag | DLRMAVEEVSLRK | 1 | |
| gatctc GTTTTGGCGA tggaggaagtctctttaagaaaatag | DLVLAMEEVSLRK | 1 | |
| gatctc TCCATGCTCC tggaggaagtctctttaagaaaatag | DLSMLLEEVSLRK | 1 | |
| gatctct CCCG ggcagtggaggaagtctctttaagaaaatag | DLSRAVEEVSLRK | 1 | |
| gatctct CTGCAGCCT tggaggaagtctctttaagaaaatag | DLSAALEEVSLRK | 1 | |
| gatctctg CAAA gcagtggaggaagtctctttaagaaaatag | DLCKAVEEVSLRK | 1 | |
| gatctctg CAAG gcagtggaggaagtctctttaagaaaatag | DLCKAVEEVSLRK | 3 | |
| gatctctg CACA gcagtggaggaagtctctttaagaaaatag | DLCTAVEEVSLRK | 1 | |
| gatctctg CACCACCT tggaggaagtctctttaagaaaatag | DLCTTLEEVSLRK | 1 | |
| gatctctg CACG gcagtggaggaagtctctttaagaaaatag | DLCTAVEEVSLRK | 1 | |
| gatctctg CACGCG agtggaggaagtctctttaagaaaatag | DLCTRVEEVSLRK | 1 | |
| gatctctg CAGA gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 6 | |
| gatctctg CAGG gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 7 | |
| gatctctg CAGTAAG gtggaggaagtctctttaagaaaatag | DLCSKVEEVSLRK | 1 | |
| gatctctg CAGTCG agtggaggaagtctctttaagaaaatag | DLCSRVEEVSLRK | 1 | |
| B | gatctctg CATG gcagtggaggaagtctctttaagaaaatag | DLCMAVEEVSLRK | 197 |
| gatctctg CCAC gcagtggaggaagtctctttaagaaaatag | DLCHAVEEVSLRK | 1 | |
| gatctctg CCAG gcagtggaggaagtctctttaagaaaatag | DLCQAVEEVSLRK | 11 | |
| gatctctg CCAGAG agtggaggaagtctctttaagaaaatag | DLCQRVEEVSLRK | 1 | |
| gatctctg CCGA gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 3 | |
| gatctctg CCGC gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 1 | |
| gatctctg CCGCCT agtggaggaagtctctttaagaaaatag | DLCRLVEEVSLRK | 1 | |
| gatctctg CCGG gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 11 | |
| gatctctg CCGTT cagtggaggaagtctctttaagaaaatag | DLCRSVEEVSLRK | 1 | |
| D | gatctctg CCTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 160 |
| gatctctg CGCC gcagtggaggaagtctctttaagaaaatag | DLCAAVEEVSLRK | 1 | |
| gatctctg CGTG gcagtggaggaagtctctttaagaaaatag | DLCVAVEEVSLRK | 3 | |
| gatctctg CTCG gcagtggaggaagtctctttaagaaaatag | DLCSAVEEVSLRK | 4 | |
| gatctctg CTGG gcagtggaggaagtctctttaagaaaatag | DLCWAVEEVSLRK | 1 | |
| gatctctg CTTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 32 | |
| gatctctg TAAA gcagtggaggaagtctctttaagaaaatag | DLCKAVEEVSLRK | 1 | |
| gatctctg TAAG gcagtggaggaagtctctttaagaaaatag | DLCKAVEEVSLRK | 7 | |
| gatctctg TACCTTCC tggaggaagtctctttaagaaaatag | DLCTFLEEVSLRK | 1 | |
| gatctctg TACG gcagtggaggaagtctctttaagaaaatag | DLCTAVEEVSLRK | 1 | |
| gatctctg TAGC gcagtggaggaagtctctttaagaaaatag | DLCSAVEEVSLRK | 1 | |
| gatctctg TAGG gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 4 | |
| gatctctg TATG gcagtggaggaagtctctttaagaaaatag | DLCMAVEEVSLRK | 18 | |
| gatctctg TCAAGACTTTCTTA aagtctctttaagaaaatag | DLCQDFLKVSLRK | 1 | |
| gatctctg TCAG gcagtggaggaagtctctttaagaaaatag | DLCQAVEEVSLRK | 9 | |
| gatctctg TCAT gcagtggaggaagtctctttaagaaaatag | DLCHAVEEVSLRK | 2 | |
| gatctctg TCGC gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 1 | |
| gatctctg TCGG gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 8 | |
| gatctctg TCGGAGTCTCGGCGGAC tctctttaagaaaatag | DLCRSLGGLSLRK | 1 | |
| gatctctg TCGT gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 1 | |
| A | gatctctg TCTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 1750 |
| gatctctg TGAC gcagtggaggaagtctctttaagaaaatag | DLCDAVEEVSLRK | 1 | |
| gatctctg TGCG gcagtggaggaagtctctttaagaaaatag | DLCAAVEEVSLRK | 1 | |
| gatctctg TGTG gcagtggaggaagtctctttaagaaaatag | DLCVAVEEVSLRK | 2 | |
| gatctctg TTCC gcagtggaggaagtctctttaagaaaatag | DLCSAVEEVSLRK | 1 | |
| gatctctg TTCG gcagtggaggaagtctctttaagaaaatag | DLCSAVEEVSLRK | 3 | |
| gatctctg TTTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 2 | |
| gatctctggca AAGGA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | 1 | |
| gatctctggca AGATTTCTTAAATC gtctctttaagaaaa tagtttaa | DLWQDFLNRLFKK IV | 1 | |
| gatctctggcag AAGT tggaggaagtctctttaagaaaatag | DLWQKLEEVSLRK | 1 | |
| gatctctggcag AGAA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | 3 | |
| gatctctggcag AGAC tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 2 | |
| gatctctggcag AGAT tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 1 | |
| gatctctggcag AGGA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | 8 | |
| gatctctggcag AGGC tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 2 | |
| gatctctggcag CGCCTT gaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 1 | |
| gatctctggcag CGCT tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 1 | |
| gatctctggcag CGGA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | 1 | |
| gatctctggcag CGGATGGC ggaagtctctttaagaaaatag | DLWQRMAEVSLRK | 1 | |
| gatctctggcag CGGC tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 1 | |
| gatctctggcag CGTCTTGGCC aagtctctttaagaaaatag | DLWQRLGQVSLRK | 1 | |
| gatctctggcag CGTTTCC aggaagtctctttaagaaaatag | DLWQRFQEVSLRK | 1 | |
| gatctctggcag GGGATAGCGATGC tctctttaagaaaatag | DLWQGIAMLSLRK | 1 | |
| gatctctggcag GGGGTGGGGAATC tctctttaagaaaatag | DLWQGVGNLSLRK | 1 | |
| gatctctggcagt CCAT ggaggaagtctctttaagaaaatag | DLWQSMEEVSLRK | 1 | |
| gatctctggcagt CCCTAGCCC aagtctctttaagaaaatag | DLWQSLAQVSLRK | 1 | |
| gatctctggcagt CCCTCTCCC aagtctctttaagaaaatag | DLWQSLSQVSLRK | 1 | |
| gatctctggcagt CCCTGGAGA aagtctctttaagaaaatag | DLWQSLEKVSLRK | 1 | |
| gatctctggcagt CCCTTTCCA aagtctctttaagaaaatag | DLWQSLSKVSLRK | 1 | |
| gatctctggcagt CCCTTTCTA aagtctctttaagaaaatag | DLWQSLSKVSLRK | 1 | |
| gatctctggcagt CTCTTGCCC aagtctctttaagaaaatag | DLWQSLAQVSLRK | 1 | |
| gatctctggcagt CTCTTTCTA aagtctctttaagaaaatag | DLWQSLSKVSLRK | 1 | |
| gatctctggcagt CTTTCGCTCAC gtctctttaagaaaatag | DLWQSFAHVSLRK | 1 | |
| gatctctggcagt TATTTTCCC aagtctctttaagaaaatag | DLWQLFSQVSLRK | 1 | |
| gatctctggcagtg CCTCGAGA aagtctctttaagaaaatag | DLWQCLEKVSLRK | 1 | |
| gatctctggcagtg CTGCTCCC aagtctctttaagaaaatag | DLWQCCSQVSLRK | 1 | |
| gatctctggcagtg TTTCTCCC aagtctctttaagaaaatag | DLWQCFSQVSLRK | 1 | |
| gatctctggcagtg TTTTGCTC aagtctctttaagaaaatag | DLWQCFAQVSLRK | 1 | |
| gatctctggcagtg TTTTTCCC aagtctctttaagaaaatag | DLWQCFSQVSLRK | 2 | |
| gatctctg CAGGCT agtggaggaagtctctttaagaaaatag | DLCRLVEEVSLRK | Rare | |
| gatctctg CCGCGG agtggaggaagtctctttaagaaaatag | DLCRGVEEVSLRK | Rare | |
| gatctctg TAGGAAG gtggaggaagtctctttaagaaaatag | DLCRKVEEVSLRK | Rare | |
| gatctctggca AAGAA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | Rare | |
| gatctctggca CCGTTTCTCC gaagtctctttaagaaaatag | DLWHRFSEVSLRK | Rare | |
| gatctctggcag ACTTTCTATA aagtctctttaagaaaatag | DLWQTFYKVSLRK | Rare | |
| gatctctggcagtg CTTCTCCA aagtctctttaagaaaatag | DLWQCFSKVSLRK | Rare |
| Type . | Nucleotide sequence of NPM1 mutations . | Translation . | Occurrence . |
|---|---|---|---|
| WT | gatctctggcagtggaggaagtctctttaa | DLWQWRKSL | NA |
| gatct ATGC ctggcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 1 | |
| gatct TTGC ctggcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 1 | |
| gatct TTGTCTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 1 | |
| gatctc ACAA tggcagtggaggaagtctctttaagaaaatag | DLTMAVEEVSLRK | 1 | |
| gatctc ATTAA ggcagtggaggaagtctctttaagaaaatag | DLIKAVEEVSLRK | 1 | |
| gatctc ATTC tggcagtggaggaagtctctttaagaaaatag | DLILAVEEVSLRK | 1 | |
| gatctc CGCA tggcagtggaggaagtctctttaagaaaatag | DLRMAVEEVSLRK | 1 | |
| gatctc GTTTTGGCGA tggaggaagtctctttaagaaaatag | DLVLAMEEVSLRK | 1 | |
| gatctc TCCATGCTCC tggaggaagtctctttaagaaaatag | DLSMLLEEVSLRK | 1 | |
| gatctct CCCG ggcagtggaggaagtctctttaagaaaatag | DLSRAVEEVSLRK | 1 | |
| gatctct CTGCAGCCT tggaggaagtctctttaagaaaatag | DLSAALEEVSLRK | 1 | |
| gatctctg CAAA gcagtggaggaagtctctttaagaaaatag | DLCKAVEEVSLRK | 1 | |
| gatctctg CAAG gcagtggaggaagtctctttaagaaaatag | DLCKAVEEVSLRK | 3 | |
| gatctctg CACA gcagtggaggaagtctctttaagaaaatag | DLCTAVEEVSLRK | 1 | |
| gatctctg CACCACCT tggaggaagtctctttaagaaaatag | DLCTTLEEVSLRK | 1 | |
| gatctctg CACG gcagtggaggaagtctctttaagaaaatag | DLCTAVEEVSLRK | 1 | |
| gatctctg CACGCG agtggaggaagtctctttaagaaaatag | DLCTRVEEVSLRK | 1 | |
| gatctctg CAGA gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 6 | |
| gatctctg CAGG gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 7 | |
| gatctctg CAGTAAG gtggaggaagtctctttaagaaaatag | DLCSKVEEVSLRK | 1 | |
| gatctctg CAGTCG agtggaggaagtctctttaagaaaatag | DLCSRVEEVSLRK | 1 | |
| B | gatctctg CATG gcagtggaggaagtctctttaagaaaatag | DLCMAVEEVSLRK | 197 |
| gatctctg CCAC gcagtggaggaagtctctttaagaaaatag | DLCHAVEEVSLRK | 1 | |
| gatctctg CCAG gcagtggaggaagtctctttaagaaaatag | DLCQAVEEVSLRK | 11 | |
| gatctctg CCAGAG agtggaggaagtctctttaagaaaatag | DLCQRVEEVSLRK | 1 | |
| gatctctg CCGA gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 3 | |
| gatctctg CCGC gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 1 | |
| gatctctg CCGCCT agtggaggaagtctctttaagaaaatag | DLCRLVEEVSLRK | 1 | |
| gatctctg CCGG gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 11 | |
| gatctctg CCGTT cagtggaggaagtctctttaagaaaatag | DLCRSVEEVSLRK | 1 | |
| D | gatctctg CCTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 160 |
| gatctctg CGCC gcagtggaggaagtctctttaagaaaatag | DLCAAVEEVSLRK | 1 | |
| gatctctg CGTG gcagtggaggaagtctctttaagaaaatag | DLCVAVEEVSLRK | 3 | |
| gatctctg CTCG gcagtggaggaagtctctttaagaaaatag | DLCSAVEEVSLRK | 4 | |
| gatctctg CTGG gcagtggaggaagtctctttaagaaaatag | DLCWAVEEVSLRK | 1 | |
| gatctctg CTTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 32 | |
| gatctctg TAAA gcagtggaggaagtctctttaagaaaatag | DLCKAVEEVSLRK | 1 | |
| gatctctg TAAG gcagtggaggaagtctctttaagaaaatag | DLCKAVEEVSLRK | 7 | |
| gatctctg TACCTTCC tggaggaagtctctttaagaaaatag | DLCTFLEEVSLRK | 1 | |
| gatctctg TACG gcagtggaggaagtctctttaagaaaatag | DLCTAVEEVSLRK | 1 | |
| gatctctg TAGC gcagtggaggaagtctctttaagaaaatag | DLCSAVEEVSLRK | 1 | |
| gatctctg TAGG gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 4 | |
| gatctctg TATG gcagtggaggaagtctctttaagaaaatag | DLCMAVEEVSLRK | 18 | |
| gatctctg TCAAGACTTTCTTA aagtctctttaagaaaatag | DLCQDFLKVSLRK | 1 | |
| gatctctg TCAG gcagtggaggaagtctctttaagaaaatag | DLCQAVEEVSLRK | 9 | |
| gatctctg TCAT gcagtggaggaagtctctttaagaaaatag | DLCHAVEEVSLRK | 2 | |
| gatctctg TCGC gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 1 | |
| gatctctg TCGG gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 8 | |
| gatctctg TCGGAGTCTCGGCGGAC tctctttaagaaaatag | DLCRSLGGLSLRK | 1 | |
| gatctctg TCGT gcagtggaggaagtctctttaagaaaatag | DLCRAVEEVSLRK | 1 | |
| A | gatctctg TCTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 1750 |
| gatctctg TGAC gcagtggaggaagtctctttaagaaaatag | DLCDAVEEVSLRK | 1 | |
| gatctctg TGCG gcagtggaggaagtctctttaagaaaatag | DLCAAVEEVSLRK | 1 | |
| gatctctg TGTG gcagtggaggaagtctctttaagaaaatag | DLCVAVEEVSLRK | 2 | |
| gatctctg TTCC gcagtggaggaagtctctttaagaaaatag | DLCSAVEEVSLRK | 1 | |
| gatctctg TTCG gcagtggaggaagtctctttaagaaaatag | DLCSAVEEVSLRK | 3 | |
| gatctctg TTTG gcagtggaggaagtctctttaagaaaatag | DLCLAVEEVSLRK | 2 | |
| gatctctggca AAGGA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | 1 | |
| gatctctggca AGATTTCTTAAATC gtctctttaagaaaa tagtttaa | DLWQDFLNRLFKK IV | 1 | |
| gatctctggcag AAGT tggaggaagtctctttaagaaaatag | DLWQKLEEVSLRK | 1 | |
| gatctctggcag AGAA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | 3 | |
| gatctctggcag AGAC tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 2 | |
| gatctctggcag AGAT tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 1 | |
| gatctctggcag AGGA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | 8 | |
| gatctctggcag AGGC tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 2 | |
| gatctctggcag CGCCTT gaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 1 | |
| gatctctggcag CGCT tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 1 | |
| gatctctggcag CGGA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | 1 | |
| gatctctggcag CGGATGGC ggaagtctctttaagaaaatag | DLWQRMAEVSLRK | 1 | |
| gatctctggcag CGGC tggaggaagtctctttaagaaaatag | DLWQRLEEVSLRK | 1 | |
| gatctctggcag CGTCTTGGCC aagtctctttaagaaaatag | DLWQRLGQVSLRK | 1 | |
| gatctctggcag CGTTTCC aggaagtctctttaagaaaatag | DLWQRFQEVSLRK | 1 | |
| gatctctggcag GGGATAGCGATGC tctctttaagaaaatag | DLWQGIAMLSLRK | 1 | |
| gatctctggcag GGGGTGGGGAATC tctctttaagaaaatag | DLWQGVGNLSLRK | 1 | |
| gatctctggcagt CCAT ggaggaagtctctttaagaaaatag | DLWQSMEEVSLRK | 1 | |
| gatctctggcagt CCCTAGCCC aagtctctttaagaaaatag | DLWQSLAQVSLRK | 1 | |
| gatctctggcagt CCCTCTCCC aagtctctttaagaaaatag | DLWQSLSQVSLRK | 1 | |
| gatctctggcagt CCCTGGAGA aagtctctttaagaaaatag | DLWQSLEKVSLRK | 1 | |
| gatctctggcagt CCCTTTCCA aagtctctttaagaaaatag | DLWQSLSKVSLRK | 1 | |
| gatctctggcagt CCCTTTCTA aagtctctttaagaaaatag | DLWQSLSKVSLRK | 1 | |
| gatctctggcagt CTCTTGCCC aagtctctttaagaaaatag | DLWQSLAQVSLRK | 1 | |
| gatctctggcagt CTCTTTCTA aagtctctttaagaaaatag | DLWQSLSKVSLRK | 1 | |
| gatctctggcagt CTTTCGCTCAC gtctctttaagaaaatag | DLWQSFAHVSLRK | 1 | |
| gatctctggcagt TATTTTCCC aagtctctttaagaaaatag | DLWQLFSQVSLRK | 1 | |
| gatctctggcagtg CCTCGAGA aagtctctttaagaaaatag | DLWQCLEKVSLRK | 1 | |
| gatctctggcagtg CTGCTCCC aagtctctttaagaaaatag | DLWQCCSQVSLRK | 1 | |
| gatctctggcagtg TTTCTCCC aagtctctttaagaaaatag | DLWQCFSQVSLRK | 1 | |
| gatctctggcagtg TTTTGCTC aagtctctttaagaaaatag | DLWQCFAQVSLRK | 1 | |
| gatctctggcagtg TTTTTCCC aagtctctttaagaaaatag | DLWQCFSQVSLRK | 2 | |
| gatctctg CAGGCT agtggaggaagtctctttaagaaaatag | DLCRLVEEVSLRK | Rare | |
| gatctctg CCGCGG agtggaggaagtctctttaagaaaatag | DLCRGVEEVSLRK | Rare | |
| gatctctg TAGGAAG gtggaggaagtctctttaagaaaatag | DLCRKVEEVSLRK | Rare | |
| gatctctggca AAGAA tggaggaagtctctttaagaaaatag | DLWQRMEEVSLRK | Rare | |
| gatctctggca CCGTTTCTCC gaagtctctttaagaaaatag | DLWHRFSEVSLRK | Rare | |
| gatctctggcag ACTTTCTATA aagtctctttaagaaaatag | DLWQTFYKVSLRK | Rare | |
| gatctctggcagtg CTTCTCCA aagtctctttaagaaaatag | DLWQCFSKVSLRK | Rare |
Inserted bases are shown in capital letters in the second column. The 4 conserved hydrophobic positions of the nuclear export signal are in bold-face type in the third column. The first base shown is c.856 from the coding reference sequence.
NA, not available.