Table 2. Blood cell indices for Townes... | American Society of Hematology

Table 2.

Blood cell indices for Townes AS BM–transplanted Cyb5R3^wt and Cyb5R3^fl chimeras before tamoxifen treatment (day −1) and at end of 3-week study

	Pretamoxifen		End of study		Statistical significance, P
	AS/R3^wt, n = 10	AS/R3^fl, n = 14	AS/R3^WT, n = 10	AS/R3^KD, n = 14	AS/R3^WT vs AS/R3^wt	AS/R3^KD vs AS/R3^fl
Hct, %	36.74 ± 0.62	34.37 ± 0.69	35.19 ± 0.56	33.58 ± 0.58	.079	.389
Hgb, g/dL	13.08 ± 0.19	12.24 ± 0.21	12.74 ± 0.27	11.88 ± 0.16	.323	.188
MCV, fL	32.67 ± 0.5	32.3 ± 0.16	33.07 ± 0.68	33.16 ± 0.26	.64	.008
RDW, %	31.56 ± 1.23	29.99 ± 0.23	33.09 ± 1.84	31.51 ± 0.51	.498	.060
MCH, pg	11.66 ± 0.69	11.51 ± 0.07	11.96 ± 0.32	11.76 ± 0.13	.492	.109
RBC, 10¹²/L	11.27 ± 0.27	10.63 ± 0.22	10.66 ± 0.15	10.12 ± 0.16	.061	.067
WBC, ×10⁹/L	18.87 ± 0.91	12.24 ± 1.20	13.67 ± 0.75	10.09 ± 0.91	.0003	.165
PLT, ×10⁹/L	1173 ± 11.1	983 ± 33.3	1208 ± 11.7	929 ± 29.9	.829	.232
MPV, fL	7.3 ± 0.06	7.13 ± 0.04	7.18 ± 0.06	7.19 ± 0.06	.299	.309

	Pretamoxifen		End of study		Statistical significance, P
	AS/R3^wt, n = 10	AS/R3^fl, n = 14	AS/R3^WT, n = 10	AS/R3^KD, n = 14	AS/R3^WT vs AS/R3^wt	AS/R3^KD vs AS/R3^fl
Hct, %	36.74 ± 0.62	34.37 ± 0.69	35.19 ± 0.56	33.58 ± 0.58	.079	.389
Hgb, g/dL	13.08 ± 0.19	12.24 ± 0.21	12.74 ± 0.27	11.88 ± 0.16	.323	.188
MCV, fL	32.67 ± 0.5	32.3 ± 0.16	33.07 ± 0.68	33.16 ± 0.26	.64	.008
RDW, %	31.56 ± 1.23	29.99 ± 0.23	33.09 ± 1.84	31.51 ± 0.51	.498	.060
MCH, pg	11.66 ± 0.69	11.51 ± 0.07	11.96 ± 0.32	11.76 ± 0.13	.492	.109
RBC, 10¹²/L	11.27 ± 0.27	10.63 ± 0.22	10.66 ± 0.15	10.12 ± 0.16	.061	.067
WBC, ×10⁹/L	18.87 ± 0.91	12.24 ± 1.20	13.67 ± 0.75	10.09 ± 0.91	.0003	.165
PLT, ×10⁹/L	1173 ± 11.1	983 ± 33.3	1208 ± 11.7	929 ± 29.9	.829	.232
MPV, fL	7.3 ± 0.06	7.13 ± 0.04	7.18 ± 0.06	7.19 ± 0.06	.299	.309

AS/R3^wt and AS/R3^fl are AS/R3^WT and AS/R3^KD groups, respectively, before tamoxifen treatment. Values are mean ± SEM using the paired Student t test.

View Large

This Feature Is Available To Subscribers Only