Proposed schema for differentiating bone marrow failure syndromes hypocellular MDS and aplastic anemia
| Cytologic/histologic variables . | Score . |
|---|---|
| Blasts ≥5% | 2 |
| Blasts 2%-4% | 1 |
| Fibrosis grade 2-3 | 1 |
| Dysmegakaryopoiesis | 1 |
| Ringed sideroblasts ≥15% | 2 |
| Ringed sideroblasts 5%-14% | 1 |
| Severe dysgranulopoiesis | 1 |
| Abnormal cytogenetics | 2 |
| MDS corresponding mutational pattern | 1 |
| Cytologic/histologic variables . | Score . |
|---|---|
| Blasts ≥5% | 2 |
| Blasts 2%-4% | 1 |
| Fibrosis grade 2-3 | 1 |
| Dysmegakaryopoiesis | 1 |
| Ringed sideroblasts ≥15% | 2 |
| Ringed sideroblasts 5%-14% | 1 |
| Severe dysgranulopoiesis | 1 |
| Abnormal cytogenetics | 2 |
| MDS corresponding mutational pattern | 1 |
Scores ≥2 are more specific for hypocellular MDS compared with AA. Adopted from Bono et al.5