Table 1. Contrasting features of... | American Society of Hematology

Table 1.

Contrasting features of hypocellular MDS vs AA

	Age	Cytogenetics	PNH clone	Blasts	Dysplasia	Macrocytosis	Somatic mutations
AA	Bimodal	Normal	20%-30%	Absent	Erythroid only	With PNH	Absent, low variant allelic frequency, absence of splicing mutations
Hypocellular MDS	Older	50% abnormal	Absent	Normal increased	Trilineage or bilineage	Prevalent	Canonical MDS hit, including spliceosomal mutations

	Age	Cytogenetics	PNH clone	Blasts	Dysplasia	Macrocytosis	Somatic mutations
AA	Bimodal	Normal	20%-30%	Absent	Erythroid only	With PNH	Absent, low variant allelic frequency, absence of splicing mutations
Hypocellular MDS	Older	50% abnormal	Absent	Normal increased	Trilineage or bilineage	Prevalent	Canonical MDS hit, including spliceosomal mutations