Table 1. Case: patient with thalassemia... | American Society of Hematology

Table 1.

Case: patient with thalassemia major with iron overload

	Iron loaded patient with thalassemia major
	Target	2017	2018	2019
Hemoglobin, gm/dL	>10 g/dL	11.6	12.0	11.5
Ferritin, ng/dL	<200 ng/dL	3000	2500	1750
t-SAT, %	<50%	60%	45%	70%
DFX, mg†	22 mg/kg/day	1440 daily	720 twice daily	720 twice daily
Liver Fe, mg/g‡	<1.5 mg/g	2.9	3.0	2.9
Pancreas R2* (Hz)	<27 Hz	240	160	90
Pit Fe Z score	0	8.2	7	6.5
Pit vol Z score	0	−3.8	−3.6	−3.6
Cardiac T2*, ms	>30 ms	15	17	24
Cardiac iron, mg/g	<0.71 mg/g	1.65	1.42	0.93
LVEF, %	>56%	58	60	58

	Iron loaded patient with thalassemia major
	Target	2017	2018	2019
Hemoglobin, gm/dL	>10 g/dL	11.6	12.0	11.5
Ferritin, ng/dL	<200 ng/dL	3000	2500	1750
t-SAT, %	<50%	60%	45%	70%
DFX, mg†	22 mg/kg/day	1440 daily	720 twice daily	720 twice daily
Liver Fe, mg/g‡	<1.5 mg/g	2.9	3.0	2.9
Pancreas R2* (Hz)	<27 Hz	240	160	90
Pit Fe Z score	0	8.2	7	6.5
Pit vol Z score	0	−3.8	−3.6	−3.6
Cardiac T2*, ms	>30 ms	15	17	24
Cardiac iron, mg/g	<0.71 mg/g	1.65	1.42	0.93
LVEF, %	>56%	58	60	58

LVEF, left ventricular ejection fraction by MRI; Pit, pituitary; t-SAT, transferrin saturation.

DFX as tablets (JadeNu). Total dose change to twice daily in 2017 (off-label use)

Based on R2*.