Mouse studies that investigated the contribution of neutrophils and NETs to venous thrombosis
| Reference . | Mouse type . | Cancer cell type . | Tumor site . | Thrombosis model . | Observation . |
|---|---|---|---|---|---|
| 41 | BALB/c | 4T1 | SC | NA | Increased neutrophil count |
| 39 | BALB/c | 4T1 | Orthotopic | NA | Increased neutrophil count and percentage of H3Cit high neutrophils. Increased NET formation after PAF stimulation |
| 39 | C57BL/6 | LLC | SC | NA | Increased neutrophil count. Increased NET formation after PAF stimulation |
| 42 | BALB/c | 4T1 | Orthotopic | Rose Bengal jugular vein | Shortened time to occlusion. DNAse I reduced thrombosis in tumor-bearing mice |
| 43 | Nude | BxPc-3 | Orthotopic | IVC stasis | Increased neutrophil count and plasma H3Cit, increased H3Cit in thrombus, reduced thrombus weight after neutrophil depletion or DNAse I treatment |
| Reference . | Mouse type . | Cancer cell type . | Tumor site . | Thrombosis model . | Observation . |
|---|---|---|---|---|---|
| 41 | BALB/c | 4T1 | SC | NA | Increased neutrophil count |
| 39 | BALB/c | 4T1 | Orthotopic | NA | Increased neutrophil count and percentage of H3Cit high neutrophils. Increased NET formation after PAF stimulation |
| 39 | C57BL/6 | LLC | SC | NA | Increased neutrophil count. Increased NET formation after PAF stimulation |
| 42 | BALB/c | 4T1 | Orthotopic | Rose Bengal jugular vein | Shortened time to occlusion. DNAse I reduced thrombosis in tumor-bearing mice |
| 43 | Nude | BxPc-3 | Orthotopic | IVC stasis | Increased neutrophil count and plasma H3Cit, increased H3Cit in thrombus, reduced thrombus weight after neutrophil depletion or DNAse I treatment |
LLC, Lewis lung carcinoma; NA, not applicable; PAF, platelet activating factor.