Considerations for use of auto-HCT and allo-HCT for indolent NHL
Auto-HCT . | Allo-HCT . |
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Both of the following: | All of the following: |
1. Chemosensitive disease | 1. Ability to achieve low disease burden before transplant, may be following novel nonchemotherapy agents. |
2. Medically fit for high-dose therapy | 2. Appropriate donor available |
AND one of the following: | 3. Medically fit/”younger” age |
1. Relapse within 24 mo of initial chemoimmunotherapy | AND one of the following: |
2. No more than third relapse | 1. Not eligible or have received prior auto-HCT |
3. Desire for time off therapy | 2. At least second relapse |
4. Short remission period after last therapy | 3. Short remission period after last therapy |
Auto-HCT . | Allo-HCT . |
---|---|
Both of the following: | All of the following: |
1. Chemosensitive disease | 1. Ability to achieve low disease burden before transplant, may be following novel nonchemotherapy agents. |
2. Medically fit for high-dose therapy | 2. Appropriate donor available |
AND one of the following: | 3. Medically fit/”younger” age |
1. Relapse within 24 mo of initial chemoimmunotherapy | AND one of the following: |
2. No more than third relapse | 1. Not eligible or have received prior auto-HCT |
3. Desire for time off therapy | 2. At least second relapse |
4. Short remission period after last therapy | 3. Short remission period after last therapy |