Table 2.

Cord blood expansion and other strategies to improve engraftment after umbilical cord blood transplantation

Agent/strategyMechanismClinical trial identifierPatients, NMedian d to PMN engraftmentInstitution, country/manufacturerAuthorReference
Nicotinamide Inhibits HSC differentiation and facilitates homing NCT01816230 36 11.5 Duke University, United States/Gamida Cell Horwitz et al 45 
Notch ligand Provides HSC proliferative signal NCT01690520 10 16 Fred Hutchinson Cancer Research Center, United States Delaney et al 43 
Mesenchymal stem cells (Mesoblasts) Provide signal for HSC expansion; improve stroma NCT01854567 31 15 MD Anderson Cancer Center, United States/Mesoblast De Lima et al 44 
16,16-dimethyl prostaglandin E2 Facilitates homing, proliferation, and self-renewal NCT00890500 12 17 Dana-Farber Cancer Institute, United States Cutler et al 53 
Oral sitagliptin DPP-IV inhibition NCT00862719 24 21 Indiana University School of Medicine, United States Farag et al 54 
Complement fragment 3a priming Facilitates homing NCT00963872 29 7 University of Minnesota, United States Brunstein et al 55 
FT-VI Fucosylation NCT01471067 22 17 MD Anderson Cancer Center, United States Popat et al 56 
Aryl hydrocarbon receptor antagonist (StemRegenin1) Blocking of HSC differentiation by SR-1 inhibition of aryl hydrocarbon receptor NCT01474681 17 15 University of Minnesota, United States Wagner et al 57 
Intrabone infusion Facilitates homing NCT00696046 32 23 University of Genoa, Italy Frassoni et al 58 
Copper chelation (carlecortemcel-L) Expansion by blocking HSC differentiation NCT00469729 101 21 Cardinal Bernardin Cancer Center, Loyola University, United States Stiff et al 59 
Agent/strategyMechanismClinical trial identifierPatients, NMedian d to PMN engraftmentInstitution, country/manufacturerAuthorReference
Nicotinamide Inhibits HSC differentiation and facilitates homing NCT01816230 36 11.5 Duke University, United States/Gamida Cell Horwitz et al 45 
Notch ligand Provides HSC proliferative signal NCT01690520 10 16 Fred Hutchinson Cancer Research Center, United States Delaney et al 43 
Mesenchymal stem cells (Mesoblasts) Provide signal for HSC expansion; improve stroma NCT01854567 31 15 MD Anderson Cancer Center, United States/Mesoblast De Lima et al 44 
16,16-dimethyl prostaglandin E2 Facilitates homing, proliferation, and self-renewal NCT00890500 12 17 Dana-Farber Cancer Institute, United States Cutler et al 53 
Oral sitagliptin DPP-IV inhibition NCT00862719 24 21 Indiana University School of Medicine, United States Farag et al 54 
Complement fragment 3a priming Facilitates homing NCT00963872 29 7 University of Minnesota, United States Brunstein et al 55 
FT-VI Fucosylation NCT01471067 22 17 MD Anderson Cancer Center, United States Popat et al 56 
Aryl hydrocarbon receptor antagonist (StemRegenin1) Blocking of HSC differentiation by SR-1 inhibition of aryl hydrocarbon receptor NCT01474681 17 15 University of Minnesota, United States Wagner et al 57 
Intrabone infusion Facilitates homing NCT00696046 32 23 University of Genoa, Italy Frassoni et al 58 
Copper chelation (carlecortemcel-L) Expansion by blocking HSC differentiation NCT00469729 101 21 Cardinal Bernardin Cancer Center, Loyola University, United States Stiff et al 59 

FT-VI, enzyme fucosyltransferase; DPP-IV, dipeptidylpeptidase IV; HSC, hematopoietic stem cell; PMN, polymorphonuclear leukocytes.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal