Table 1. Evidence supporting the... | American Society of Hematology

Table 1.

Evidence supporting the prognostic value of geriatric domains and specific metrics in older AML patients

Metric	References	Outcome	Patients	Therapy	Data source
Comorbidities
CCI	11	ED, CR, OS	n = 133, age ≥ 70 y	Intensive	Retrospective
	12	ED, OS	n = 5480, age ≥ 65 y	Variable	Registry
	13	No effect on ED, CR	n = 2792, all ages	Variable	Registry
	14	No effect on ED, OS	n = 144, age ≥ 60 y	Intensive	Retrospective
HCTCI	15	ED, OS	n = 177, age ≥ 60 y	Intensive	Retrospective
	16	OS	n = 416, age ≥ 65 y	Intensive	Retrospective
	17	ED, OS	n = 80, age > 55 y	Intensive	Retrospective
Augmented HCTCI	18	ED, OS	n = 1100, all ages	Variable	Retrospective
Diabetes	14	ED	n = 144, age ≥ 60 y	Intensive	Retrospective
Physical function
IADL	19	OS	n = 63, all ages	Variable	Prospective
IADL	20	OS	n = 101, age ≥ 65 y	Variable	Retrospective
ADL	21	OS	n = 195, age ≥ 60 y, AML and MDS	Variable	Prospective
SPPB	22	OS	n = 74, age ≥ 60 y	Intensive	Prospective
Modified SPPB	23	No effect on OS	n = 97, age ≥ 60 y	Intensive	Prospective
Cognition
Modified MMSE	22	OS	n = 74, age ≥ 60 y	Intensive	Prospective
Polypharmacy
No. medications	24	ED, CR, OS	n = 150, age ≥ 60 y	Intensive	Retrospective

Metric	References	Outcome	Patients	Therapy	Data source
Comorbidities
CCI	11	ED, CR, OS	n = 133, age ≥ 70 y	Intensive	Retrospective
	12	ED, OS	n = 5480, age ≥ 65 y	Variable	Registry
	13	No effect on ED, CR	n = 2792, all ages	Variable	Registry
	14	No effect on ED, OS	n = 144, age ≥ 60 y	Intensive	Retrospective
HCTCI	15	ED, OS	n = 177, age ≥ 60 y	Intensive	Retrospective
	16	OS	n = 416, age ≥ 65 y	Intensive	Retrospective
	17	ED, OS	n = 80, age > 55 y	Intensive	Retrospective
Augmented HCTCI	18	ED, OS	n = 1100, all ages	Variable	Retrospective
Diabetes	14	ED	n = 144, age ≥ 60 y	Intensive	Retrospective
Physical function
IADL	19	OS	n = 63, all ages	Variable	Prospective
IADL	20	OS	n = 101, age ≥ 65 y	Variable	Retrospective
ADL	21	OS	n = 195, age ≥ 60 y, AML and MDS	Variable	Prospective
SPPB	22	OS	n = 74, age ≥ 60 y	Intensive	Prospective
Modified SPPB	23	No effect on OS	n = 97, age ≥ 60 y	Intensive	Prospective
Cognition
Modified MMSE	22	OS	n = 74, age ≥ 60 y	Intensive	Prospective
Polypharmacy
No. medications	24	ED, CR, OS	n = 150, age ≥ 60 y	Intensive	Retrospective

ADL, activities of daily living; CCI, Charlson Comorbidity Index; CR, complete remission; ED, early death; HCTCI, Hematopoietic Cell Transplant Comorbidity Index; IADL, instrumental activities of daily living; MMSE, Mini-Mental Status Examination; OS, overall survival; SPPB, Short Physical Performance Battery.

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