Indications to start therapy in a patient with a diagnosis of WM
| Clinical indications for initiation of therapy . |
|---|
| Recurrent fever, night sweats, weight loss, fatigue |
| Hyperviscosity |
| Lymphadenopathy: either symptomatic or bulky (≥5 cm in maximum diameter) |
| Symptomatic hepatomegaly and/or splenomegaly |
| Symptomatic organomegaly and/or organ or tissue infiltration |
| Peripheral neuropathy because of WM |
| Clinical indications for initiation of therapy . |
|---|
| Recurrent fever, night sweats, weight loss, fatigue |
| Hyperviscosity |
| Lymphadenopathy: either symptomatic or bulky (≥5 cm in maximum diameter) |
| Symptomatic hepatomegaly and/or splenomegaly |
| Symptomatic organomegaly and/or organ or tissue infiltration |
| Peripheral neuropathy because of WM |
| Laboratory indications for initiation of therapy . |
|---|
| Symptomatic cryoglobulinemia |
| Symptomatic cold agglutinin anemia |
| Autoimmune hemolytic anemia and/or thrombocytopenia |
| Nephropathy that is related to WM |
| Amyloidosis that is related to WM |
| Hemoglobin ≤10 g/dL |
| Platelet count <100 × 109/L |
| Laboratory indications for initiation of therapy . |
|---|
| Symptomatic cryoglobulinemia |
| Symptomatic cold agglutinin anemia |
| Autoimmune hemolytic anemia and/or thrombocytopenia |
| Nephropathy that is related to WM |
| Amyloidosis that is related to WM |
| Hemoglobin ≤10 g/dL |
| Platelet count <100 × 109/L |
Indications to start therapy are according to consensus criteria first published by Kyle et al31 and further confirmed in 201998 and in 2016.32