Indications to start therapy in a patient with a diagnosis of WM
Clinical indications for initiation of therapy . |
---|
Recurrent fever, night sweats, weight loss, fatigue |
Hyperviscosity |
Lymphadenopathy: either symptomatic or bulky (≥5 cm in maximum diameter) |
Symptomatic hepatomegaly and/or splenomegaly |
Symptomatic organomegaly and/or organ or tissue infiltration |
Peripheral neuropathy because of WM |
Clinical indications for initiation of therapy . |
---|
Recurrent fever, night sweats, weight loss, fatigue |
Hyperviscosity |
Lymphadenopathy: either symptomatic or bulky (≥5 cm in maximum diameter) |
Symptomatic hepatomegaly and/or splenomegaly |
Symptomatic organomegaly and/or organ or tissue infiltration |
Peripheral neuropathy because of WM |
Laboratory indications for initiation of therapy . |
---|
Symptomatic cryoglobulinemia |
Symptomatic cold agglutinin anemia |
Autoimmune hemolytic anemia and/or thrombocytopenia |
Nephropathy that is related to WM |
Amyloidosis that is related to WM |
Hemoglobin ≤10 g/dL |
Platelet count <100 × 109/L |
Laboratory indications for initiation of therapy . |
---|
Symptomatic cryoglobulinemia |
Symptomatic cold agglutinin anemia |
Autoimmune hemolytic anemia and/or thrombocytopenia |
Nephropathy that is related to WM |
Amyloidosis that is related to WM |
Hemoglobin ≤10 g/dL |
Platelet count <100 × 109/L |
Indications to start therapy are according to consensus criteria first published by Kyle et al31 and further confirmed in 201998 and in 2016.32