Clinical and laboratory findings of symptomatic WM
| Characteristics of patients with symptomatic WM . | N = 595 . |
|---|---|
| Age, median/range, y | 69 (24-92) |
| Male/female, % | 60/40 |
| BM involvement, median | 52% |
| MYD88 L265P* (N = 84) | 77% |
| IgM, median | 3480 mg/dL |
| IgG, median | 790 mg/dL |
| IgA, median | 85 mg/dL |
| Hemoglobin, median | 10.1 g/dL |
| Hemoglobin <10 g/dL | 46% |
| Platelets, ×109/L, median | 215 |
| Platelets, <100 × 109/L | 12% |
| WBC, ×109/L, median | 6.6 |
| b2-microglobulin, median | 3.36 mg/dL |
| Serum albumin | 3.6 g/dL |
| Serum albumin <3.5 g/dL | 40% |
| LDH, U/L (ULN < 225 IU/L), median | 180 |
| LDH > ULN | 20% |
| Cryoglobulins present | 5.5% |
| Cold agglutinins present | 4% |
| Lymphadenopathy | 36% |
| Splenomegaly | 29% |
| Clinical presentation at the time of symptomatic disease: main indication for therapy (in many patients more than 1 reason was present) | |
| Anemia/cytopenias | 42% |
| B-symptoms | 25% |
| Hyperviscosity | 17% |
| Neuropathy | 12% |
| Amyloidosis | 1.5% |
| Symptomatic cryoglobulinemia | 1.3% |
| Symptomatic cold agglutinin disease | 0.6% |
| Other | 0.6% |
| Characteristics of patients with symptomatic WM . | N = 595 . |
|---|---|
| Age, median/range, y | 69 (24-92) |
| Male/female, % | 60/40 |
| BM involvement, median | 52% |
| MYD88 L265P* (N = 84) | 77% |
| IgM, median | 3480 mg/dL |
| IgG, median | 790 mg/dL |
| IgA, median | 85 mg/dL |
| Hemoglobin, median | 10.1 g/dL |
| Hemoglobin <10 g/dL | 46% |
| Platelets, ×109/L, median | 215 |
| Platelets, <100 × 109/L | 12% |
| WBC, ×109/L, median | 6.6 |
| b2-microglobulin, median | 3.36 mg/dL |
| Serum albumin | 3.6 g/dL |
| Serum albumin <3.5 g/dL | 40% |
| LDH, U/L (ULN < 225 IU/L), median | 180 |
| LDH > ULN | 20% |
| Cryoglobulins present | 5.5% |
| Cold agglutinins present | 4% |
| Lymphadenopathy | 36% |
| Splenomegaly | 29% |
| Clinical presentation at the time of symptomatic disease: main indication for therapy (in many patients more than 1 reason was present) | |
| Anemia/cytopenias | 42% |
| B-symptoms | 25% |
| Hyperviscosity | 17% |
| Neuropathy | 12% |
| Amyloidosis | 1.5% |
| Symptomatic cryoglobulinemia | 1.3% |
| Symptomatic cold agglutinin disease | 0.6% |
| Other | 0.6% |
Data are from the database of the Greek Myeloma Study Group.