Selected active and recent CD123-targeting immunotherapy trials
| . | Product . | Company/Institution . | Phase . | Trial . | Status . | Results (ORR) . | Notes . |
|---|---|---|---|---|---|---|---|
| Monoclonal antibody | Talacotuzumab | Xencor/J&J | 3 | NCT01632852 | Completed | 20% | Discontinued (efficacy) |
| KHK2823 | KHK | 1 | NCT02181699 | Not yet recruiting | |||
| Antibody-drug conjugate | SGN-CD123A | Seattle Genetics | 1 | NCT02848248 | Terminated | ||
| IMGN632 | ImmunoGen | 1 | NCT03386513 | Recruiting | 33% | ||
| Protein drug conjugate | Tagraxofusp (SL-401) | Stemline Therapeutics | 1/2 | NCT02270463 | Recruiting | 3 deaths (BPDCN) | |
| Bispecific antibody | Flotetuzumab | MacroGenics | 1 | NCT02152956 | Recruiting | 26% | |
| JNJ-63709178 | Genmab/J&J | 1 | NCT02715011 | Recruiting | Hold/lifted | ||
| XmAb14045 | Xencor/Novartis | 1 | NCT02730312 | Hold | 23% | Hold/2 deaths | |
| CAR T cell | UCART123 | Cellectis (MD Anderson Cancer Center) | 1 | NCT03190278 | Recruiting | Hold/lifted 1 death (BPDCN) | |
| MB-102 | Mustang Bio (City of Hope) | 1 | NCT02159495 | Recruiting | |||
| CD123CART | University of Pennsylvania | 1 | NCT03766126 | Recruiting |
| . | Product . | Company/Institution . | Phase . | Trial . | Status . | Results (ORR) . | Notes . |
|---|---|---|---|---|---|---|---|
| Monoclonal antibody | Talacotuzumab | Xencor/J&J | 3 | NCT01632852 | Completed | 20% | Discontinued (efficacy) |
| KHK2823 | KHK | 1 | NCT02181699 | Not yet recruiting | |||
| Antibody-drug conjugate | SGN-CD123A | Seattle Genetics | 1 | NCT02848248 | Terminated | ||
| IMGN632 | ImmunoGen | 1 | NCT03386513 | Recruiting | 33% | ||
| Protein drug conjugate | Tagraxofusp (SL-401) | Stemline Therapeutics | 1/2 | NCT02270463 | Recruiting | 3 deaths (BPDCN) | |
| Bispecific antibody | Flotetuzumab | MacroGenics | 1 | NCT02152956 | Recruiting | 26% | |
| JNJ-63709178 | Genmab/J&J | 1 | NCT02715011 | Recruiting | Hold/lifted | ||
| XmAb14045 | Xencor/Novartis | 1 | NCT02730312 | Hold | 23% | Hold/2 deaths | |
| CAR T cell | UCART123 | Cellectis (MD Anderson Cancer Center) | 1 | NCT03190278 | Recruiting | Hold/lifted 1 death (BPDCN) | |
| MB-102 | Mustang Bio (City of Hope) | 1 | NCT02159495 | Recruiting | |||
| CD123CART | University of Pennsylvania | 1 | NCT03766126 | Recruiting |
ORR, overall response rate.