Patient baseline characteristics, and treatment and bleed history, by hemophilia type
| . | HA . | HAwI . | HBwI . |
|---|---|---|---|
| Patients, N* | 36 | 9 | 8 |
| Mean age at baseline (SD), y | 36.9 (12.9) | 38.0 (12.1) | 29.8 (8.5) |
| Mean body weight (SD), kg | 77.0 (20.4) | 75.3 (13.8) | 67.1 (10.2) |
| Mean time from diagnosis (SD), y | 34.4 (12.1) | 37.4 (12.8) | 29.0 (8.5) |
| Patients on prophylaxis, n | 31 | 1 | 1 |
| Prophylaxis mean ABR (min; max) | 5.2 (0; 52) | 8.6 | 0.0 |
| Patients treated on demand, n | 10 | 9 | 8 |
| On-demand mean ABR (min; max)† | 17.5 (4; 47) | 17.2 (6; 39) | 34.3 (6; 120) |
| On-demand median ABR | 10 | 18 | 24 |
| . | HA . | HAwI . | HBwI . |
|---|---|---|---|
| Patients, N* | 36 | 9 | 8 |
| Mean age at baseline (SD), y | 36.9 (12.9) | 38.0 (12.1) | 29.8 (8.5) |
| Mean body weight (SD), kg | 77.0 (20.4) | 75.3 (13.8) | 67.1 (10.2) |
| Mean time from diagnosis (SD), y | 34.4 (12.1) | 37.4 (12.8) | 29.0 (8.5) |
| Patients on prophylaxis, n | 31 | 1 | 1 |
| Prophylaxis mean ABR (min; max) | 5.2 (0; 52) | 8.6 | 0.0 |
| Patients treated on demand, n | 10 | 9 | 8 |
| On-demand mean ABR (min; max)† | 17.5 (4; 47) | 17.2 (6; 39) | 34.3 (6; 120) |
| On-demand median ABR | 10 | 18 | 24 |
Patient baseline characteristics and treatment and bleed history by hemophilia type in explorer4 (HAwI, HBwI) and explorer5 (HAwI) (concizumab-treated patients only; full analysis set).
max, maximum; min, minimum; SD, standard deviation.
Patients were permitted to be treated with >1 treatment regimen during the 12 months prior to screening.
During the treatment regimen.