Table 2.

EC50 values of LAM-003–induced degradation of WT FLT3 and FLT3 mutants in BA/F3 cells

Client proteinEC50, nM
WT FLT3 3590 
FLT3-ITD 751 
FLT3 D835V 406 
FLT3-ITD D835V 545 
FLT3 D835Y 509 
FLT3-ITD D835Y 504 
FLT3 D835H 662 
FLT3-ITD D835H 440 
FLT3 F691L 662 
FLT3-ITD F691L 448 
Client proteinEC50, nM
WT FLT3 3590 
FLT3-ITD 751 
FLT3 D835V 406 
FLT3-ITD D835V 545 
FLT3 D835Y 509 
FLT3-ITD D835Y 504 
FLT3 D835H 662 
FLT3-ITD D835H 440 
FLT3 F691L 662 
FLT3-ITD F691L 448 
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