Table 1. Phenotypes of Wt, Hri −/− , eAA... | American Society of Hematology

Table 1.

Phenotypes of Wt, Hri^−/−, eAA, and Atf4^−/− mice in ID

	Genotypes
	Wt	Hri^−/−	eAA	Atf4^−/−
Phenotypes in ID	Wt	Universal knockout	Erythroid knockin of Ser51/Ala	Universal knockout
Viability	Normal	Normal	Normal	Perinatal Lethality
Anemia	Microcytic	Macrocytic	Macrocytic	Microcytic
Globin inclusion	No	Yes	Yes	No
Serum Epo	Low	Increased	Increased	Increased
BM erythropoiesis	Reduced	Ineffective	Ineffective	Ineffective
Spleen erythropoiesis	Enhanced	Ineffective	Ineffective	Ineffective
ROS erythroid	Low	Elevated	Elevated	Elevated
mTORC1	Low	High	High	High

	Genotypes
	Wt	Hri^−/−	eAA	Atf4^−/−
Phenotypes in ID	Wt	Universal knockout	Erythroid knockin of Ser51/Ala	Universal knockout
Viability	Normal	Normal	Normal	Perinatal Lethality
Anemia	Microcytic	Macrocytic	Macrocytic	Microcytic
Globin inclusion	No	Yes	Yes	No
Serum Epo	Low	Increased	Increased	Increased
BM erythropoiesis	Reduced	Ineffective	Ineffective	Ineffective
Spleen erythropoiesis	Enhanced	Ineffective	Ineffective	Ineffective
ROS erythroid	Low	Elevated	Elevated	Elevated
mTORC1	Low	High	High	High

BM, bone marrow.