Table 5. Parameters of thrombin... | American Society of Hematology

Table 5.

Parameters of thrombin generation in murine PRP

	WT (n = 7)*	PN-1^−/− (n = 6)^*	F8^−/− (n = 7)^*	F8^−/−/PN-1^−/− (n = 6)^*	F8^−/−(n = 10)
	WT (n = 7)*	PN-1^−/− (n = 6)^*	F8^−/− (n = 7)^*	F8^−/−/PN-1^−/− (n = 6)^*	PRP alone†	PRP + irrelevant IgG†	PRP + anti-PN-1†
Lag time, min	5.47 ± 1.82	5.12 ± 2.07	7.34 ± 2.84	6.26 ± 1.23	2.43 ± 1.06	5.63 ± 7.21	2.78 ± 1.18
Peak, nM	10.36 ± 4.47	19.53 ± 9.29	3.05 ± 2.44	3.30 ± 3.69	2.38 ± 1.71	2.17 ± 1.82	2.40 ± 1.97
TTP, min	12.80 ± 2.86	11.12 ± 3.02	11.96 ± 1.98	11.71 ± 2.02	7.05 ± 3.38	9.51 ± 7.45	7.12 ± 3.40
ETP, nM.min	179.5 ± 47.62	222.3 ± 120.4	31.11 ± 35.25	25.95 ± 10.45	29.55 ± 23.69	25.83 ± 23.19	27.10 ± 22.17
Velocity, nM/min	1.64 ± 0.79	3.35 ± 2.15	0.44 ± 0.26	0.58 ± 0.41	0.48 ± 0.37	0.42 ± 0.35	0.47 ± 0.28

	WT (n = 7)*	PN-1^−/− (n = 6)^*	F8^−/− (n = 7)^*	F8^−/−/PN-1^−/− (n = 6)^*	F8^−/−(n = 10)
	WT (n = 7)*	PN-1^−/− (n = 6)^*	F8^−/− (n = 7)^*	F8^−/−/PN-1^−/− (n = 6)^*	PRP alone†	PRP + irrelevant IgG†	PRP + anti-PN-1†
Lag time, min	5.47 ± 1.82	5.12 ± 2.07	7.34 ± 2.84	6.26 ± 1.23	2.43 ± 1.06	5.63 ± 7.21	2.78 ± 1.18
Peak, nM	10.36 ± 4.47	19.53 ± 9.29	3.05 ± 2.44	3.30 ± 3.69	2.38 ± 1.71	2.17 ± 1.82	2.40 ± 1.97
TTP, min	12.80 ± 2.86	11.12 ± 3.02	11.96 ± 1.98	11.71 ± 2.02	7.05 ± 3.38	9.51 ± 7.45	7.12 ± 3.40
ETP, nM.min	179.5 ± 47.62	222.3 ± 120.4	31.11 ± 35.25	25.95 ± 10.45	29.55 ± 23.69	25.83 ± 23.19	27.10 ± 22.17
Velocity, nM/min	1.64 ± 0.79	3.35 ± 2.15	0.44 ± 0.26	0.58 ± 0.41	0.48 ± 0.37	0.42 ± 0.35	0.47 ± 0.28

Thrombin generation was triggered by TF. Means ± SD.

A Mann-Whitney test was used here.

A nonparametric 1-way ANOVA test followed by a multiple comparison test was used here.