Parameters of thrombin generation in PRP from patients with severe hemophilia A and B with collagen-induced platelet activation
| . | PRP alone . | PRP + irrelevant IgG . | PRP + anti-PN-1 . |
|---|---|---|---|
| Patients with severe hemophilia A (n = 6) | |||
| Lag time, min | 12.48 ± 4.61 | 12.14 ± 4.72 | 11.23 ± 4.70 |
| Peak, nM | 22.59 ± 11.66 | 23.59 ± 11.65 | 31.49 ± 16.20* |
| TTP, min | 40.30 ± 5.67 | 39.90 ± 5.49 | 34.94 ± 6.31* |
| ETP, nM⋅min | 1060 ± 587.0 | 1103 ± 579.0 | 1172 ± 581.9 |
| Velocity, nM/min | 0.81 ± 0.39 | 0.88 ± 0.41 | 1.39 ± 0.81* |
| Patients with severe hemophilia B (n =3) | |||
| Lag time, min | 8.85 ± 1.08 | 8.39 ± 1.08 | 8.30 ± 1.75 |
| Peak, nM | 19.56 ± 6.64 | 19.56 ± 6.11 | 38.95 ± 10.62 |
| TTP, min | 29.59 ± 0.92 | 28.30 ± 1.45 | 26.04 ± 2.93* |
| ETP, nM⋅min | 1046 ± 243.2 | 926.1 ± 300.3 | 1429 ± 194.0* |
| Velocity, nM/min | 1.05 ± 0.31 | 0.99 ± 0.32 | 2.23 ± 0.78 |
| . | PRP alone . | PRP + irrelevant IgG . | PRP + anti-PN-1 . |
|---|---|---|---|
| Patients with severe hemophilia A (n = 6) | |||
| Lag time, min | 12.48 ± 4.61 | 12.14 ± 4.72 | 11.23 ± 4.70 |
| Peak, nM | 22.59 ± 11.66 | 23.59 ± 11.65 | 31.49 ± 16.20* |
| TTP, min | 40.30 ± 5.67 | 39.90 ± 5.49 | 34.94 ± 6.31* |
| ETP, nM⋅min | 1060 ± 587.0 | 1103 ± 579.0 | 1172 ± 581.9 |
| Velocity, nM/min | 0.81 ± 0.39 | 0.88 ± 0.41 | 1.39 ± 0.81* |
| Patients with severe hemophilia B (n =3) | |||
| Lag time, min | 8.85 ± 1.08 | 8.39 ± 1.08 | 8.30 ± 1.75 |
| Peak, nM | 19.56 ± 6.64 | 19.56 ± 6.11 | 38.95 ± 10.62 |
| TTP, min | 29.59 ± 0.92 | 28.30 ± 1.45 | 26.04 ± 2.93* |
| ETP, nM⋅min | 1046 ± 243.2 | 926.1 ± 300.3 | 1429 ± 194.0* |
| Velocity, nM/min | 1.05 ± 0.31 | 0.99 ± 0.32 | 2.23 ± 0.78 |
Means ± SD. A nonparametric 1-way ANOVA test followed by a multiple comparison test was used.
P < .05 vs PRP + irrelevant IgG.