Table 1. Parameters of thrombin... | American Society of Hematology

Table 1.

Parameters of thrombin generation in PRP from patients with mild and moderate hemophilia A

	Patients with mild hemophilia A (n = 10)			Patients with moderate hemophilia A (n = 6)
	PRP alone	PRP + irrelevant IgG	PRP + anti-PN-1	PRP alone	PRP + irrelevant IgG	PRP + anti-PN-1
Lag time, min	10.32 ± 2.92	10.33 ± 2.96	10.32 ± 3.02	11.98 ± 1.70	12.09 ± 1.70	11.89 ± 1.83
Peak, nM	87.68 ± 32.70	87.16 ± 35.19	110.8 ± 42.10*	75.05 ± 21.33	71.88 ± 24.37	96.25 ± 32.91†
TTP, min	23.23 ± 5.09	23.34 ± 5.07	21.55 ± 4.68‡	25.41 ± 4.63	25.73 ± 4.82	22.92 ± 4.30†
ETP, nM⋅min	1485 ± 381.0	1474 ± 382.2	1442 ± 374.2	1341 ± 448.0	1288 ± 452.6	1299 ± 410.6
Velocity, nM/min	7.26 ± 3.63	7.07 ± 3.64	10.99 ± 6.63*	5.77 ± 2.24	5.56 ± 2.67	9.19 ± 4.65†

	Patients with mild hemophilia A (n = 10)			Patients with moderate hemophilia A (n = 6)
	PRP alone	PRP + irrelevant IgG	PRP + anti-PN-1	PRP alone	PRP + irrelevant IgG	PRP + anti-PN-1
Lag time, min	10.32 ± 2.92	10.33 ± 2.96	10.32 ± 3.02	11.98 ± 1.70	12.09 ± 1.70	11.89 ± 1.83
Peak, nM	87.68 ± 32.70	87.16 ± 35.19	110.8 ± 42.10*	75.05 ± 21.33	71.88 ± 24.37	96.25 ± 32.91†
TTP, min	23.23 ± 5.09	23.34 ± 5.07	21.55 ± 4.68‡	25.41 ± 4.63	25.73 ± 4.82	22.92 ± 4.30†
ETP, nM⋅min	1485 ± 381.0	1474 ± 382.2	1442 ± 374.2	1341 ± 448.0	1288 ± 452.6	1299 ± 410.6
Velocity, nM/min	7.26 ± 3.63	7.07 ± 3.64	10.99 ± 6.63*	5.77 ± 2.24	5.56 ± 2.67	9.19 ± 4.65†

Means ± SD. A nonparametric 1-way ANOVA test followed by a multiple comparison test was used.

P < .01.

P < .05.

P < .001 vs PRP + irrelevant IgG.