Effects of hydroxyurea treatment
| . | Month 0 . | Month 3 . | Month 6 . | Month 9 . | Month 12 . |
|---|---|---|---|---|---|
| No. of children | 48 | 48 | 48 | 46 | 30 |
| Hydroxyurea dose, mg/kg/day [mean (SD)] | 20.2 (1.2) | 19.7 (1.2) | 20.9 (3.2) | 22.5 (4.5) | 25.0 (6.1) |
| Laboratory values [mean (SD)] | |||||
| Hb, g/dL | 7.5 (0.9) | 8.3 (1.1) | 8.4 (1.2) | 8.7 (1.4) | 8.6 (1.3) |
| MCV, fL | 89 (7) | 98 (9) | 98 (9) | 99 (10) | 99 (10) |
| HbF (F+S), % | 15.8 (7.7) | 24.7 (9.4) | 26.8 (9.9) | 25.6 (10.4) | 28.1 (12.3) |
| ARC, ×109/L | 216 (93) | 156 (59) | 164 (70) | 151 (70) | 143 (62) |
| WBC, ×109/L | 16.0 (6.4) | 11.9 (3.3) | 11.2 (3.5) | 10.6 (4.4) | 10.1 (3.9) |
| ANC, ×109/L | 7.9 (3.5) | 6.2 (2.6) | 5.9 (2.4) | 5.7 (3.8) | 5.2 (2.8) |
| Platelets, ×109/L | 448 (154) | 403 (176) | 388 (160) | 377 (143) | 355 (145) |
| ALT, IU/L | 19 (7) | 25 (35) | 20 (13) | 16 (6) | 20 (12) |
| Creatinine, mg/dL | 0.4 (0.2) | 0.3 (0.1) | 0.4 (01) | 0.4 (0.1) | 0.4 (0.1) |
| . | Month 0 . | Month 3 . | Month 6 . | Month 9 . | Month 12 . |
|---|---|---|---|---|---|
| No. of children | 48 | 48 | 48 | 46 | 30 |
| Hydroxyurea dose, mg/kg/day [mean (SD)] | 20.2 (1.2) | 19.7 (1.2) | 20.9 (3.2) | 22.5 (4.5) | 25.0 (6.1) |
| Laboratory values [mean (SD)] | |||||
| Hb, g/dL | 7.5 (0.9) | 8.3 (1.1) | 8.4 (1.2) | 8.7 (1.4) | 8.6 (1.3) |
| MCV, fL | 89 (7) | 98 (9) | 98 (9) | 99 (10) | 99 (10) |
| HbF (F+S), % | 15.8 (7.7) | 24.7 (9.4) | 26.8 (9.9) | 25.6 (10.4) | 28.1 (12.3) |
| ARC, ×109/L | 216 (93) | 156 (59) | 164 (70) | 151 (70) | 143 (62) |
| WBC, ×109/L | 16.0 (6.4) | 11.9 (3.3) | 11.2 (3.5) | 10.6 (4.4) | 10.1 (3.9) |
| ANC, ×109/L | 7.9 (3.5) | 6.2 (2.6) | 5.9 (2.4) | 5.7 (3.8) | 5.2 (2.8) |
| Platelets, ×109/L | 448 (154) | 403 (176) | 388 (160) | 377 (143) | 355 (145) |
| ALT, IU/L | 19 (7) | 25 (35) | 20 (13) | 16 (6) | 20 (12) |
| Creatinine, mg/dL | 0.4 (0.2) | 0.3 (0.1) | 0.4 (01) | 0.4 (0.1) | 0.4 (0.1) |
Eligible children with conditional TCD velocities have had expected changes in their laboratory values, and many now have normal TCD velocities.
ALT, alanine aminotransferase; ANC, absolute neutrophil count; ARC, absolute reticulocyte count; Hb, hemoglobin; HbF, fetal hemoglobin; MCV, mean cell volume; WBC, white blood cell count.