Multivariable analyses for factors independently associated with RFS and OS
| Variable . | HR . | 95% CI . | P . |
|---|---|---|---|
| RFS | |||
| FLT3-ITD mutation | 1.963 | 1.281-3.007 | .002 |
| SCT in first CR | 0.399 | 0.000-0.628 | <.0001 |
| DN vs myeloid phenotype | 0.365 | 0.000-0.666 | .001 |
| Monocytic phenotype without TET/IDH comutation vs myeloid phenotype | 0.305 | 0.000-0.550 | <.0001 |
| Monocytic phenotype with TET/IDH comutation vs myeloid phenotype | 0.757 | 0.445-1.287 | .303 |
| OS | |||
| FLT3-ITD mutation | 1.751 | 1.076-2.850 | .024 |
| Age at diagnosis (continuous, per y) | 1.030 | 1.008-1.052 | .006 |
| DN vs myeloid phenotype | 0.417 | 0.000-0.802 | .009 |
| Monocytic phenotype without TET/IDH comutation vs myeloid phenotype | 0.476 | 0.000-0.903 | .023 |
| Monocytic phenotype with TET/IDH comutation vs myeloid phenotype | 0.854 | 0.453-1.609 | .624 |
| Variable . | HR . | 95% CI . | P . |
|---|---|---|---|
| RFS | |||
| FLT3-ITD mutation | 1.963 | 1.281-3.007 | .002 |
| SCT in first CR | 0.399 | 0.000-0.628 | <.0001 |
| DN vs myeloid phenotype | 0.365 | 0.000-0.666 | .001 |
| Monocytic phenotype without TET/IDH comutation vs myeloid phenotype | 0.305 | 0.000-0.550 | <.0001 |
| Monocytic phenotype with TET/IDH comutation vs myeloid phenotype | 0.757 | 0.445-1.287 | .303 |
| OS | |||
| FLT3-ITD mutation | 1.751 | 1.076-2.850 | .024 |
| Age at diagnosis (continuous, per y) | 1.030 | 1.008-1.052 | .006 |
| DN vs myeloid phenotype | 0.417 | 0.000-0.802 | .009 |
| Monocytic phenotype without TET/IDH comutation vs myeloid phenotype | 0.476 | 0.000-0.903 | .023 |
| Monocytic phenotype with TET/IDH comutation vs myeloid phenotype | 0.854 | 0.453-1.609 | .624 |
CI, confidence interval; HR, hazard ratio.