Table 5.

Association between the rate of clinical events and the crude and adjusted RRs in the study population according to metformin adherence levels

Clinical eventsCrude RR (95% CI)Adjusted RR* (95% CI)
MPR ≥ 40% to < 80%MPR ≥ 80%MPR ≥ 40% to < 80%MPR ≥ 80%
All-cause inpatient encounters 0.58 (0.27-1.22) 0.33 (0.07-1.49) 0.62 (0.29-1.31) 0.38 (0.09-1.71) 
Inpatient encounters with SCD codes 0.64 (0.23-1.83) 0.41 (0.05-3.34) 0.53 (0.17-1.69) 0.28 (0.03-2.84) 
All-cause ED encounters 0.94 (0.53-1.67) 0.88 (0.28-2.79) 0.68 (0.40-1.13) 0.46 (0.16-1.28) 
ED encounters with SCD codes 0.58 (0.19-1.74) 0.34 (0.04-3.04) 0.74 (0.24-2.30) 0.55 (0.06-5.31) 
Clinical eventsCrude RR (95% CI)Adjusted RR* (95% CI)
MPR ≥ 40% to < 80%MPR ≥ 80%MPR ≥ 40% to < 80%MPR ≥ 80%
All-cause inpatient encounters 0.58 (0.27-1.22) 0.33 (0.07-1.49) 0.62 (0.29-1.31) 0.38 (0.09-1.71) 
Inpatient encounters with SCD codes 0.64 (0.23-1.83) 0.41 (0.05-3.34) 0.53 (0.17-1.69) 0.28 (0.03-2.84) 
All-cause ED encounters 0.94 (0.53-1.67) 0.88 (0.28-2.79) 0.68 (0.40-1.13) 0.46 (0.16-1.28) 
ED encounters with SCD codes 0.58 (0.19-1.74) 0.34 (0.04-3.04) 0.74 (0.24-2.30) 0.55 (0.06-5.31) 
*

The reference group is the patient group with MPR < 40%.

RR and 95% CI adjusted for age group, sex, and Charlson Comorbidity Index score.

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