Table 4.

Association between metformin adherence groups and the rate of clinical events in the study population

Clinical eventsAdherence to metformin (MPR)
MPR <40%, n = 42MPR ≥40% to <80%, n = 49MPR ≥80%, n = 37P
Rate of all-cause inpatient encounters per year, median (IQR) 1 (0-2) 0 (0-1) 0 (0-1) .13 
All-cause inpatient encounters ≥1, n (%) 22 (52) 16 (33) 16 (43) .16 
Rate of inpatient encounters with SCD codes per year, median (IQR) 0 (0-1) 0 (0-0) 0 (0-0) <.01 
Inpatient encounters with SCD codes ≥1, n (%) 15 (36) 6 (12) 4 (11) <.01 
Rate of all-cause ED encounters per year, median (IQR) 2 (1-7) 1 (1-4) 1 (1-4) .17 
All-cause ED encounters ≥1, n (%) 34 (81) 37 (76) 28 (76) .79 
Rate of ED encounters with SCD codes per year, median (IQR) 0 (0-1) 0 (0-0) 0 (0-0) .19 
ED encounters with SCD codes ≥1, n (%) 11 (26) 10 (20) 4 (11) .22 
Clinical eventsAdherence to metformin (MPR)
MPR <40%, n = 42MPR ≥40% to <80%, n = 49MPR ≥80%, n = 37P
Rate of all-cause inpatient encounters per year, median (IQR) 1 (0-2) 0 (0-1) 0 (0-1) .13 
All-cause inpatient encounters ≥1, n (%) 22 (52) 16 (33) 16 (43) .16 
Rate of inpatient encounters with SCD codes per year, median (IQR) 0 (0-1) 0 (0-0) 0 (0-0) <.01 
Inpatient encounters with SCD codes ≥1, n (%) 15 (36) 6 (12) 4 (11) <.01 
Rate of all-cause ED encounters per year, median (IQR) 2 (1-7) 1 (1-4) 1 (1-4) .17 
All-cause ED encounters ≥1, n (%) 34 (81) 37 (76) 28 (76) .79 
Rate of ED encounters with SCD codes per year, median (IQR) 0 (0-1) 0 (0-0) 0 (0-0) .19 
ED encounters with SCD codes ≥1, n (%) 11 (26) 10 (20) 4 (11) .22 

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