Table 1. Summary of coagulation factors... | American Society of Hematology

Table 1.

Summary of coagulation factors and platelet-mediated pathogenesis of SCD

Coagulation factors	Mechanism of action	Effects on SCD	References
TF/FXa	Initiates coagulation system activation	Indirectly induces inflammation, organ damage	19, 132
Thrombin/fibrinogen	Activates PAR-1, -3, -4, and fibrinogen by proteolytic cleavage; induces secretion of inflammatory cytokines and chemokines from platelets and leukocytes	Inflammation, organ damage	15, 59
Platelets	Forms aggregates with neutrophils and monocytes; secretes inflammatory cytokines and chemokines	Inflammation, pulmonary hypertension, thrombosis, organ damage	68, 85, 91

Coagulation factors	Mechanism of action	Effects on SCD	References
TF/FXa	Initiates coagulation system activation	Indirectly induces inflammation, organ damage	19, 132
Thrombin/fibrinogen	Activates PAR-1, -3, -4, and fibrinogen by proteolytic cleavage; induces secretion of inflammatory cytokines and chemokines from platelets and leukocytes	Inflammation, organ damage	15, 59
Platelets	Forms aggregates with neutrophils and monocytes; secretes inflammatory cytokines and chemokines	Inflammation, pulmonary hypertension, thrombosis, organ damage	68, 85, 91