Multivariate analysis of TRM and ATL-related mortalities in patients receiving allogeneic HSCT
| Variable . | TRM . | ATL-related mortality . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. . | HR . | 95% CI . | P . | No. . | HR . | 95% CI . | P . | |
| Age range at transplantation, y | ||||||||
| 15-55 | 116/362 | 1.000 | Reference | 93/362 | 1.000 | Reference | ||
| 56-72 | 79/210 | 1.403 | (0.954-2.064) | .085 | 62/210 | 0.955 | (0.658-1.385) | .810 |
| Sex | ||||||||
| Female | 75/262 | 1.000 | Reference | 66/262 | 1.000 | Reference | ||
| Male | 120/310 | 1.383 | (1.026-1.863) | .033 | 89/310 | 1.226 | (0.886-1.697) | .220 |
| Disease status at transplantation | ||||||||
| CR | 58/205 | 1.000 | Reference | 32/205 | 1.000 | Reference | ||
| Non-CR | 121/330 | 1.238 | (0.906-1.691) | 0.180 | 114/330 | 2.203 | (1.469-3.302) | < .001 |
| Unknown | 16/37 | 1.507 | (0.873-2.603) | 0.140 | 9/37 | 1.511 | (0.663-3.444) | .330 |
| PS | ||||||||
| 0 | 54/213 | 1.000 | Reference | 44/213 | 1.000 | Reference | ||
| 1 | 91/260 | 1.509 | (1.075-2.118) | .017 | 74/260 | 1.272 | (0.872-1.856) | .210 |
| 2-4 | 41/75 | 3.004 | (1.915-4.714) | < .001 | 30/75 | 1.679 | (1.035-2.723) | .036 |
| Unknown | 9/24 | 1.214 | (0.614-2.403) | 0.580 | 7/24 | 1.965 | (0.802-4.818) | .140 |
| Relationship between recipient and donor | ||||||||
| HLA-matched related | 62/206 | 1.000 | Reference | 60/206 | 1.000 | Reference | ||
| HLA-mismatched related | 18/62 | 0.924 | (0.532-1.606) | 0.780 | 26/62 | 1.392 | (0.873-2.220) | .160 |
| Unrelated | 115/304 | 1.429 | (1.033-1.975) | .031 | 69/304 | 0.843 | (0.589-1.209) | .350 |
| Preconditioning regimen | ||||||||
| MAC | 100/274 | 1.000 | Reference | 61/275 | 1.000 | Reference | ||
| RIC | 95/298 | 0.786 | (0.538-1.148) | 0.210 | 94/304 | 1.579 | (1.080-2.308) | .019 |
| Variable . | TRM . | ATL-related mortality . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. . | HR . | 95% CI . | P . | No. . | HR . | 95% CI . | P . | |
| Age range at transplantation, y | ||||||||
| 15-55 | 116/362 | 1.000 | Reference | 93/362 | 1.000 | Reference | ||
| 56-72 | 79/210 | 1.403 | (0.954-2.064) | .085 | 62/210 | 0.955 | (0.658-1.385) | .810 |
| Sex | ||||||||
| Female | 75/262 | 1.000 | Reference | 66/262 | 1.000 | Reference | ||
| Male | 120/310 | 1.383 | (1.026-1.863) | .033 | 89/310 | 1.226 | (0.886-1.697) | .220 |
| Disease status at transplantation | ||||||||
| CR | 58/205 | 1.000 | Reference | 32/205 | 1.000 | Reference | ||
| Non-CR | 121/330 | 1.238 | (0.906-1.691) | 0.180 | 114/330 | 2.203 | (1.469-3.302) | < .001 |
| Unknown | 16/37 | 1.507 | (0.873-2.603) | 0.140 | 9/37 | 1.511 | (0.663-3.444) | .330 |
| PS | ||||||||
| 0 | 54/213 | 1.000 | Reference | 44/213 | 1.000 | Reference | ||
| 1 | 91/260 | 1.509 | (1.075-2.118) | .017 | 74/260 | 1.272 | (0.872-1.856) | .210 |
| 2-4 | 41/75 | 3.004 | (1.915-4.714) | < .001 | 30/75 | 1.679 | (1.035-2.723) | .036 |
| Unknown | 9/24 | 1.214 | (0.614-2.403) | 0.580 | 7/24 | 1.965 | (0.802-4.818) | .140 |
| Relationship between recipient and donor | ||||||||
| HLA-matched related | 62/206 | 1.000 | Reference | 60/206 | 1.000 | Reference | ||
| HLA-mismatched related | 18/62 | 0.924 | (0.532-1.606) | 0.780 | 26/62 | 1.392 | (0.873-2.220) | .160 |
| Unrelated | 115/304 | 1.429 | (1.033-1.975) | .031 | 69/304 | 0.843 | (0.589-1.209) | .350 |
| Preconditioning regimen | ||||||||
| MAC | 100/274 | 1.000 | Reference | 61/275 | 1.000 | Reference | ||
| RIC | 95/298 | 0.786 | (0.538-1.148) | 0.210 | 94/304 | 1.579 | (1.080-2.308) | .019 |