Impact of E2 treatment on platelet counts in wild-type mice or hematopoietic chimeras
| . | −E2 . | +E2 . | . |
|---|---|---|---|
| WT, n = 21 | 5.7 ± 0.25 | 4.3 ± 0.21 | P < .001 |
| ERα−/−→WT, n = 3 | 4.8 ± 0.24 | 5.4 ± 0.53 | NS |
| ERβ−/−→WT, n = 2 | 4.8/4.7 | 4/6 | NA |
| . | −E2 . | +E2 . | . |
|---|---|---|---|
| WT, n = 21 | 5.7 ± 0.25 | 4.3 ± 0.21 | P < .001 |
| ERα−/−→WT, n = 3 | 4.8 ± 0.24 | 5.4 ± 0.53 | NS |
| ERβ−/−→WT, n = 2 | 4.8/4.7 | 4/6 | NA |
Platelets counts (×108 platelets/mL) were determined by counting cells in a Malassez chamber after platelet isolation.
E2 indicates estradiol; WT, wild type; NS, not significant; and NA, not applicable.