Immunophenotypic genotypic characteristics and NOTCH1/FBXW7 status of adult T-ALL as a function of TCR translocation
| . | n . | T-ALL TCRβ translocated, n (%) . | T-ALL TCRδ translocated, n (%) . | T-ALL TCRβ/δ nontranslocated, n (%) . |
|---|---|---|---|---|
| T-ALL patients | 280 | 40 (14%) | 38 (13%) | 205 (73%) |
| Median age, y | 18 | 19,5 | 24 | 17 |
| TCR subset analysis | ||||
| Immature | 58 | 4 (7%) | 1 (2%) | 53 (91%) |
| IMβ/pre-αβ | 143 | 26 (18%) | 31 (22%) | 89 (60%) |
| TCRγδ | 40 | 7 (18%) | 1 (2%) | 32 (80%) |
| TCRαβ | 35 | 3 (9%) | 4 (11%) | 28 (80%) |
| ND | 4 | 0 | 1 | 3 |
| Genotype subset analysis | ||||
| PICALM-MLLT10 | 18 | 2 (11%)* | 0 | 16 (89%) |
| STIL-TAL1 | 30 | 2 (7%)† | 2 (7%)‡ | 26 (86%) |
| TLX1 | 39 | 11 (28%)§ | 21 (54%)§ | 7 (18%) |
| TLX3 | 47 | 1 (2%) | 1 (2%)¶ | 45 (96%) |
| None of above | 146 | 22 (15%) | 14 (9%) | 111 (76%) |
| NOTCH1 FBXW7 mutation | ||||
| NOTCH1 and/or FBXW7 mutated | 150 | 25 (71%) | 24 (83%) | 101 (63%) |
| NOTCH1 and FBXW7 unmutated | 73 | 10 (14%) | 5 (7%) | 61 (84%) |
| ND | 57 | 5 | 9 | 43 |
| . | n . | T-ALL TCRβ translocated, n (%) . | T-ALL TCRδ translocated, n (%) . | T-ALL TCRβ/δ nontranslocated, n (%) . |
|---|---|---|---|---|
| T-ALL patients | 280 | 40 (14%) | 38 (13%) | 205 (73%) |
| Median age, y | 18 | 19,5 | 24 | 17 |
| TCR subset analysis | ||||
| Immature | 58 | 4 (7%) | 1 (2%) | 53 (91%) |
| IMβ/pre-αβ | 143 | 26 (18%) | 31 (22%) | 89 (60%) |
| TCRγδ | 40 | 7 (18%) | 1 (2%) | 32 (80%) |
| TCRαβ | 35 | 3 (9%) | 4 (11%) | 28 (80%) |
| ND | 4 | 0 | 1 | 3 |
| Genotype subset analysis | ||||
| PICALM-MLLT10 | 18 | 2 (11%)* | 0 | 16 (89%) |
| STIL-TAL1 | 30 | 2 (7%)† | 2 (7%)‡ | 26 (86%) |
| TLX1 | 39 | 11 (28%)§ | 21 (54%)§ | 7 (18%) |
| TLX3 | 47 | 1 (2%) | 1 (2%)¶ | 45 (96%) |
| None of above | 146 | 22 (15%) | 14 (9%) | 111 (76%) |
| NOTCH1 FBXW7 mutation | ||||
| NOTCH1 and/or FBXW7 mutated | 150 | 25 (71%) | 24 (83%) | 101 (63%) |
| NOTCH1 and FBXW7 unmutated | 73 | 10 (14%) | 5 (7%) | 61 (84%) |
| ND | 57 | 5 | 9 | 43 |