Reactions underlying the FVII-dependent inhibition of FXa generation
| Reaction . | Effect on FVII-dependent inhibition . | |
|---|---|---|
| Reaction was disabled . | Reaction was accelerated . | |
| Competition of FVII and FVIIa for TF | No inhibition | Increased inhibition |
| Activation of FVII or FVII/TF | Higher inhibition | No inhibition |
| Activation of FX by FVIIa/TF | No inhibition | No effect |
| Activation of FX by FVIIa/phospholipid | No effect but FXa integral was lower at the highest rFVIIa concentrations | No effect on inhibition but FXa integrals were higher at higher rFVIIa |
| Inactivation of FXa by AT3 and TFPI | No effect but FXa integral was higher | No effect but FXa integral was lower |
| Inactivation of FVIIa/TF by TFPI/Xa | No effect but FXa integral was higher | No effect but FXa integral was lower |
| Reversal of inactivation of FVIIa/TF by TFPI/Xa | No effect but FXa integral was lower | No effect but FXa integral was higher |
| Reaction . | Effect on FVII-dependent inhibition . | |
|---|---|---|
| Reaction was disabled . | Reaction was accelerated . | |
| Competition of FVII and FVIIa for TF | No inhibition | Increased inhibition |
| Activation of FVII or FVII/TF | Higher inhibition | No inhibition |
| Activation of FX by FVIIa/TF | No inhibition | No effect |
| Activation of FX by FVIIa/phospholipid | No effect but FXa integral was lower at the highest rFVIIa concentrations | No effect on inhibition but FXa integrals were higher at higher rFVIIa |
| Inactivation of FXa by AT3 and TFPI | No effect but FXa integral was higher | No effect but FXa integral was lower |
| Inactivation of FVIIa/TF by TFPI/Xa | No effect but FXa integral was higher | No effect but FXa integral was lower |
| Reversal of inactivation of FVIIa/TF by TFPI/Xa | No effect but FXa integral was lower | No effect but FXa integral was higher |
Experiments were simulated under conditions in which each of the reactions was disabled or enhanced.
TFPI indicates TF pathway inhibitor.