Summary of overall risk groups
| Disease risk . | Stage risk . | % of patients . | Overall risk . | 4-y OS (95% CI), P < .001 . | 4-y PFS (95% CI), P < .001 . | 4-y CIR (95% CI), P < .001 . | 4-y NRM (95% CI), P = .11 . |
|---|---|---|---|---|---|---|---|
| Low | Low | 15 | Low | 64% (56%-70%) | 56% (48%-63%) | 19% (13%-24%) | 26% (19%-32%) |
| Low | High | 10 | Intermediate | 46% (42%-50%) | 40% (36%-43%) | 36% (33%-40%) | 24% (21%-27%) |
| Intermediate | Low | 45 | |||||
| Intermediate | High | 17 | High | 26% (21%-31%) | 18% (14%-22%) | 55% (50%-60%) | 27% (22%-32%) |
| High | Low | 10 | |||||
| High | High | 3 | Very high | 6% (0%-21%) | 6% (0%-21%) | 63% (44%-81%) | 31% (18%-45%) |
| Disease risk . | Stage risk . | % of patients . | Overall risk . | 4-y OS (95% CI), P < .001 . | 4-y PFS (95% CI), P < .001 . | 4-y CIR (95% CI), P < .001 . | 4-y NRM (95% CI), P = .11 . |
|---|---|---|---|---|---|---|---|
| Low | Low | 15 | Low | 64% (56%-70%) | 56% (48%-63%) | 19% (13%-24%) | 26% (19%-32%) |
| Low | High | 10 | Intermediate | 46% (42%-50%) | 40% (36%-43%) | 36% (33%-40%) | 24% (21%-27%) |
| Intermediate | Low | 45 | |||||
| Intermediate | High | 17 | High | 26% (21%-31%) | 18% (14%-22%) | 55% (50%-60%) | 27% (22%-32%) |
| High | Low | 10 | |||||
| High | High | 3 | Very high | 6% (0%-21%) | 6% (0%-21%) | 63% (44%-81%) | 31% (18%-45%) |
95% CI indicates 95% confidence interval; CIR, cumulative incidence of relapse; NRM, cumulative incidence of nonrelapse mortality; OS, overall survival; and PFS, progression-free survival.