Absolute and relative contraindications to anticoagulant prophylaxis
| Active bleeding* |
| Lumbar puncture/epidural/spinal anesthesia within the previous 4 hours or expected within the next 12 hours* |
| Concurrent use of anticoagulants known to increase the risk of bleeding (eg, warfarin with INR > 2)* |
| Acquired bleeding disorders (eg, acute liver failure) |
| Mucosal lesions (eg, active peptic ulceration, bronchiectasis) |
| Acute stroke (within 24 hours) |
| Thrombocytopenia (platelets < 75 × 109/L) |
| Uncontrolled systolic hypertension (≥ 230/120 mmHg) |
| Untreated inherited bleeding disorders (eg, hemophilia or von Willebrand disease) |
| Active bleeding* |
| Lumbar puncture/epidural/spinal anesthesia within the previous 4 hours or expected within the next 12 hours* |
| Concurrent use of anticoagulants known to increase the risk of bleeding (eg, warfarin with INR > 2)* |
| Acquired bleeding disorders (eg, acute liver failure) |
| Mucosal lesions (eg, active peptic ulceration, bronchiectasis) |
| Acute stroke (within 24 hours) |
| Thrombocytopenia (platelets < 75 × 109/L) |
| Uncontrolled systolic hypertension (≥ 230/120 mmHg) |
| Untreated inherited bleeding disorders (eg, hemophilia or von Willebrand disease) |
Absolute contraindications.