Table 1

Summary of LANA-specific CD4+ T-cell clones

DonorPeptide poolAmino acid coordinates*PeptideRestrictionFunctional avidity
B1 P 36-50 GDDLHLQPRRKHVAD DR13 10−7 
B1 Q 76-90 PAFVSSPTLPVAPIP DQ6 10−7 
B1 R 191-205 LAPSTLRSLRKRRLS DP1 10−8 
B1 S 196-210 LRSLRKRRLSSPQGP DR13 10−6 
B1 R/S 191- LAPSTLRSLRKRRLS DQ6 10−8 
  -210 LRSLRKRRLSSPQGP   
B1 T 276-290 WGDDTAMLVLLAEIA DQ6 10−8 
B1 V 981-996 EYRYVLRTSPPHRPG DQ6 10−8 
B1 W 1052-1066 CQWKFAVIFWGNDPY DR52c 10−6 
B1 W 1077-1091 FGGVKAGPVSCLPHP DP11 nd 
G48 Q 66-80 GSPTVFTSGLPAFVS DQ7 10−7 
G48 Q 76-90 PAFVSSPTLPVAPIP DQ7 10−6 
G29 Q 76-90 PAFVSSPTLPVAPIP DR52b 10−8 
G18 W 1047-1061 RRDPKCQWKFAVIFW nd nd 
DonorPeptide poolAmino acid coordinates*PeptideRestrictionFunctional avidity
B1 P 36-50 GDDLHLQPRRKHVAD DR13 10−7 
B1 Q 76-90 PAFVSSPTLPVAPIP DQ6 10−7 
B1 R 191-205 LAPSTLRSLRKRRLS DP1 10−8 
B1 S 196-210 LRSLRKRRLSSPQGP DR13 10−6 
B1 R/S 191- LAPSTLRSLRKRRLS DQ6 10−8 
  -210 LRSLRKRRLSSPQGP   
B1 T 276-290 WGDDTAMLVLLAEIA DQ6 10−8 
B1 V 981-996 EYRYVLRTSPPHRPG DQ6 10−8 
B1 W 1052-1066 CQWKFAVIFWGNDPY DR52c 10−6 
B1 W 1077-1091 FGGVKAGPVSCLPHP DP11 nd 
G48 Q 66-80 GSPTVFTSGLPAFVS DQ7 10−7 
G48 Q 76-90 PAFVSSPTLPVAPIP DQ7 10−6 
G29 Q 76-90 PAFVSSPTLPVAPIP DR52b 10−8 
G18 W 1047-1061 RRDPKCQWKFAVIFW nd nd 

nd indicates not determined.

*

Coordinate location based on the BC-1 LANA sequence.

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