Sensitivity and specificity of fecal markers to diagnose GI-GVHD
| . | AUROC (95% CI) . | Threshold . | Sensitivity, % (95% CI) . | Specificity, % (95% CI) . |
|---|---|---|---|---|
| Gut GVHD any stage | ||||
| Calprotectin | 0.623 (0.491-0.756) | > 100 μg/g | 31 (19-46) | 90 (70-99) |
| Elastase | 0.683 (0.560-0.805) | < 200 μg/g | 43 (29-58) | 90 (70-99) |
| α1-antitrypsin | 0.699 (0.577-0.822) | > 1.5 mg/g | 59 (44-72) | 62 (38-82) |
| Gut GVHD stage 2-3 | ||||
| Calprotectin | 0.661 (0.524-0.798) | > 100 μg/g | 46 (28-66) | 89 (75-96) |
| Elastase | 0.824 (0.728-0.920) | < 200 μg/g | 64 (44-81) | 86 (73-95) |
| α1-antitrypsin | 0.808 (0.698-0.917) | > 1.5 mg/g | 79 (59-62) | 64 (48-78) |
| . | AUROC (95% CI) . | Threshold . | Sensitivity, % (95% CI) . | Specificity, % (95% CI) . |
|---|---|---|---|---|
| Gut GVHD any stage | ||||
| Calprotectin | 0.623 (0.491-0.756) | > 100 μg/g | 31 (19-46) | 90 (70-99) |
| Elastase | 0.683 (0.560-0.805) | < 200 μg/g | 43 (29-58) | 90 (70-99) |
| α1-antitrypsin | 0.699 (0.577-0.822) | > 1.5 mg/g | 59 (44-72) | 62 (38-82) |
| Gut GVHD stage 2-3 | ||||
| Calprotectin | 0.661 (0.524-0.798) | > 100 μg/g | 46 (28-66) | 89 (75-96) |
| Elastase | 0.824 (0.728-0.920) | < 200 μg/g | 64 (44-81) | 86 (73-95) |
| α1-antitrypsin | 0.808 (0.698-0.917) | > 1.5 mg/g | 79 (59-62) | 64 (48-78) |
GI indicates gastrointestinal; AUROC, area under the Receiver Operating Characteristics curve; and CI, confidence interval.