Representative set of enriched miRNA-binding sites present in transcripts that are a source of MIPs in B-LCLs from both sibships
| 3′-UTR–binding site . | miRNA . | Sibship 1 . | Sibship 2 . | ||||
|---|---|---|---|---|---|---|---|
| n . | RE . | P . | n . | RE . | P . | ||
| TGCACTT | MIR-519C MIR-519B MIR-519A | 51 | 4.21 | 5.93 × 10−18 | 9 | 2.23 | 2.15 × 10−02 |
| ACATTCC | MIR-1 MIR-206 | 40 | 4.94 | 8.63 × 10−17 | 11 | 4.07 | 9.95 × 10−05 |
| TGCCTTA | MIR-124A | 53 | 3.53 | 2.87 × 10−15 | 11 | 5.02 | 1.31 × 10−02 |
| CTTGTAT | MIR-381 | 30 | 5.64 | 1.66 × 10−14 | 5 | 2.81 | 3.36 × 10−02 |
| ACCAAAG | MIR-9 | 48 | 3.48 | 9.38 × 10−14 | 16 | 3.48 | 2.01 × 10−05 |
| TAGCTTT | MIR-9 | 48 | 3.48 | 9.38 × 10−14 | 16 | 3.48 | 1.95 × 10−02 |
| TGAATGT | MIR-181A MIR-181B MIR-181C MIR-181D | 47 | 3.51 | 1.23 × 10−13 | 9 | 2.01 | 3.72 × 10−02 |
| GTGCCTT | MIR-506 | 57 | 2.93 | 7.65 × 10−13 | 20 | 3.08 | 1.16 × 10−05 |
| ACTTTAT | MIR-142-5P | 34 | 4.28 | 1.18 × 10−12 | 11 | 4.15 | 8.38 × 10−05 |
| TTTGCAC | MIR-19A MIR-19B | 46 | 3.28 | 2.41 × 10−12 | 14 | 2.99 | 3.00 × 10−04 |
| TTTGTAG | MIR-520D | 35 | 3.93 | 6.75 × 10−12 | 7 | 2.36 | 3.08 × 10−02 |
| GTATTAT | MIR-369-3P | 25 | 4.51 | 3.62 × 10−10 | 6 | 3.24 | 1.11 × 10−02 |
| GTTTGTT | MIR-495 | 27 | 4.05 | 8.41 × 10−10 | 8 | 3.6 | 1.90 × 10−03 |
| TTTGCAG | MIR-518A-2 | 24 | 4.33 | 1.88 × 10−09 | 7 | 3.79 | 2.70 × 10−03 |
| CTTTGTA | MIR-524 | 36 | 3.01 | 5.82 × 10−09 | 13 | 3.26 | 2.00 × 10−04 |
| CAGTGTT | MIR-141 MIR-200A | 28 | 3.33 | 3.32 × 10−08 | 10 | 3.57 | 6.00 × 10−04 |
| TATTATA | MIR-374 | 26 | 3.44 | 5.41 × 10−08 | 8 | 3.17 | 4.10 × 10−03 |
| TTTTGAG | MIR-373 | 23 | 3.77 | 5.75 × 10−08 | 8 | 3.93 | 1.10 × 10−03 |
| CTCAGGG | MIR-125B MIR-125A | 28 | 3.20 | 7.76 × 10−08 | 7 | 2.4 | 2.84 × 10−02 |
| TGTTTAC | MIR-30A-5P MIR-30C MIR-30D MIR-30B MIR-30E-5P | 40 | 2.54 | 9.80 × 10−08 | 11 | 2.09 | 1.78 × 10−02 |
| TGGTGCT | MIR-29A MIR-29B MIR-29C | 37 | 2.65 | 9.83 × 10−08 | 12 | 2.58 | 2.80 × 10−03 |
| GCAAAAA | MIR-129 | 20 | 4.09 | 1.07 × 10−07 | 6 | 3.68 | 6.20 × 10−03 |
| ATTCTTT | MIR-186 | 25 | 3.35 | 1.63 × 10−07 | 6 | 2.41 | 4.03 × 10−02 |
| ATACTGT | MIR-144 | 21 | 3.81 | 1.77 × 10−07 | 10 | 5.44 | 1.83 × 10−05 |
| 3′-UTR–binding site . | miRNA . | Sibship 1 . | Sibship 2 . | ||||
|---|---|---|---|---|---|---|---|
| n . | RE . | P . | n . | RE . | P . | ||
| TGCACTT | MIR-519C MIR-519B MIR-519A | 51 | 4.21 | 5.93 × 10−18 | 9 | 2.23 | 2.15 × 10−02 |
| ACATTCC | MIR-1 MIR-206 | 40 | 4.94 | 8.63 × 10−17 | 11 | 4.07 | 9.95 × 10−05 |
| TGCCTTA | MIR-124A | 53 | 3.53 | 2.87 × 10−15 | 11 | 5.02 | 1.31 × 10−02 |
| CTTGTAT | MIR-381 | 30 | 5.64 | 1.66 × 10−14 | 5 | 2.81 | 3.36 × 10−02 |
| ACCAAAG | MIR-9 | 48 | 3.48 | 9.38 × 10−14 | 16 | 3.48 | 2.01 × 10−05 |
| TAGCTTT | MIR-9 | 48 | 3.48 | 9.38 × 10−14 | 16 | 3.48 | 1.95 × 10−02 |
| TGAATGT | MIR-181A MIR-181B MIR-181C MIR-181D | 47 | 3.51 | 1.23 × 10−13 | 9 | 2.01 | 3.72 × 10−02 |
| GTGCCTT | MIR-506 | 57 | 2.93 | 7.65 × 10−13 | 20 | 3.08 | 1.16 × 10−05 |
| ACTTTAT | MIR-142-5P | 34 | 4.28 | 1.18 × 10−12 | 11 | 4.15 | 8.38 × 10−05 |
| TTTGCAC | MIR-19A MIR-19B | 46 | 3.28 | 2.41 × 10−12 | 14 | 2.99 | 3.00 × 10−04 |
| TTTGTAG | MIR-520D | 35 | 3.93 | 6.75 × 10−12 | 7 | 2.36 | 3.08 × 10−02 |
| GTATTAT | MIR-369-3P | 25 | 4.51 | 3.62 × 10−10 | 6 | 3.24 | 1.11 × 10−02 |
| GTTTGTT | MIR-495 | 27 | 4.05 | 8.41 × 10−10 | 8 | 3.6 | 1.90 × 10−03 |
| TTTGCAG | MIR-518A-2 | 24 | 4.33 | 1.88 × 10−09 | 7 | 3.79 | 2.70 × 10−03 |
| CTTTGTA | MIR-524 | 36 | 3.01 | 5.82 × 10−09 | 13 | 3.26 | 2.00 × 10−04 |
| CAGTGTT | MIR-141 MIR-200A | 28 | 3.33 | 3.32 × 10−08 | 10 | 3.57 | 6.00 × 10−04 |
| TATTATA | MIR-374 | 26 | 3.44 | 5.41 × 10−08 | 8 | 3.17 | 4.10 × 10−03 |
| TTTTGAG | MIR-373 | 23 | 3.77 | 5.75 × 10−08 | 8 | 3.93 | 1.10 × 10−03 |
| CTCAGGG | MIR-125B MIR-125A | 28 | 3.20 | 7.76 × 10−08 | 7 | 2.4 | 2.84 × 10−02 |
| TGTTTAC | MIR-30A-5P MIR-30C MIR-30D MIR-30B MIR-30E-5P | 40 | 2.54 | 9.80 × 10−08 | 11 | 2.09 | 1.78 × 10−02 |
| TGGTGCT | MIR-29A MIR-29B MIR-29C | 37 | 2.65 | 9.83 × 10−08 | 12 | 2.58 | 2.80 × 10−03 |
| GCAAAAA | MIR-129 | 20 | 4.09 | 1.07 × 10−07 | 6 | 3.68 | 6.20 × 10−03 |
| ATTCTTT | MIR-186 | 25 | 3.35 | 1.63 × 10−07 | 6 | 2.41 | 4.03 × 10−02 |
| ATACTGT | MIR-144 | 21 | 3.81 | 1.77 × 10−07 | 10 | 5.44 | 1.83 × 10−05 |
The WebGestalt analysis tool was used to calculate the enrichment. P values were calculated using the hypergeometric test.
n indicates the number of transcripts that were a source of MIPs containing the 3′-UTR–binding site recognized by the specified miRNAs; and RE, ratio of enrichment (observed/expected number of transcripts).