The licensed recombinant FVIII concentrates
| Cell line . | Baby hamster kidney cells . | Chinese hamster ovary cells . | |
|---|---|---|---|
| . | . | ||
| FVIII gene length | Full length | Full length | B-domain deleted |
| First generation | Kogenate | Recombinate | — |
| Helixate | |||
| Second generation | Kogenate FS | — | Refacto |
| Helixate FS/ | |||
| Helixate NextGen | |||
| Third generation | — | Advate | Xyntha/Refacto AF |
| Cell line . | Baby hamster kidney cells . | Chinese hamster ovary cells . | |
|---|---|---|---|
| . | . | ||
| FVIII gene length | Full length | Full length | B-domain deleted |
| First generation | Kogenate | Recombinate | — |
| Helixate | |||
| Second generation | Kogenate FS | — | Refacto |
| Helixate FS/ | |||
| Helixate NextGen | |||
| Third generation | — | Advate | Xyntha/Refacto AF |
— indicates no available concentrate.