Table 1 Blood counts from adult Mcl-1 /... | American Society of Hematology

Table 1

Blood counts from adult Mcl-1^+/+, Mcl-1^fl/fl, and Mcl-1^Pf4Δ/Pf4Δ mice at steady state and 48 hours after single-dose ABT-737 treatment

	Untreated			ABT-737
	Mcl-1^+/+, n = 13	Mcl-1^fl/fl, n = 20	Mcl-1^Pf4Δ/Pf4Δ, n = 20	Mcl-1^+/+, n = 7	Mcl-1^fl/fl, n = 6	Mcl-1^Pf4Δ/Pf4Δ, n = 6
Platelets, ×10⁶/mL	1228 ± 263	1092 ± 150	1156 ± 235	644 ± 198	686 ± 252	99 ± 106*
MPV, fL	7.4 ± 1.0	7.7 ± 0.7	7.6 ± 0.9	7.1 ± 0.4	7.1 ± 0.9	9.9 ± 3.3
PDW, %	50.3 ± 4.4	52.8 ± 3.9	51.7 ± 4.8	47.0 ± 4.2	53.0 ± 6.6	88.6 ± 22.4*
Erythrocytes, ×10⁹/mL	10.8 ± 0.4	11.0 ± 0.6	11.2 ± 0.4	10.9 ± 0.3	11.3 ± 0.3	11.0 ± 2.4
Hematocrit, %	50.4 ± 2.3	52.9 ± 4.7	52.9 ± 3.7	55.4 ± 2.3	50.4 ± 1.4	48.7 ± 10.0
Neutrophils, ×10⁶/mL	0.9 ± 0.6	1.0 ± 0.3	1.2 ± 0.5	0.6 ± 0.2	0.9 ± 0.2	1.0 ± 0.3†
Lymphocytes, ×10⁶/mL	7.3 ± 1.7	9.7 ± 1.6*	9.7 ± 1.3*	2.9 ± 1.5	5.2 ± 1.6	4.4 ± 1.9
Monocytes, ×10⁶/mL	0.2 ± 0.1	0.2 ± 0.1	0.2 ± 0.1	0.1 ± 0.0	0.1 ± 0.0	0.2 ± 0.0
Eosinophils, ×10⁶/mL	0.2 ± 0.1	0.2 ± 0.1	0.2 ± 0.1	0.2 ± 0.0	0.2 ± 0.0	0.2 ± 0.1

	Untreated			ABT-737
	Mcl-1^+/+, n = 13	Mcl-1^fl/fl, n = 20	Mcl-1^Pf4Δ/Pf4Δ, n = 20	Mcl-1^+/+, n = 7	Mcl-1^fl/fl, n = 6	Mcl-1^Pf4Δ/Pf4Δ, n = 6
Platelets, ×10⁶/mL	1228 ± 263	1092 ± 150	1156 ± 235	644 ± 198	686 ± 252	99 ± 106*
MPV, fL	7.4 ± 1.0	7.7 ± 0.7	7.6 ± 0.9	7.1 ± 0.4	7.1 ± 0.9	9.9 ± 3.3
PDW, %	50.3 ± 4.4	52.8 ± 3.9	51.7 ± 4.8	47.0 ± 4.2	53.0 ± 6.6	88.6 ± 22.4*
Erythrocytes, ×10⁹/mL	10.8 ± 0.4	11.0 ± 0.6	11.2 ± 0.4	10.9 ± 0.3	11.3 ± 0.3	11.0 ± 2.4
Hematocrit, %	50.4 ± 2.3	52.9 ± 4.7	52.9 ± 3.7	55.4 ± 2.3	50.4 ± 1.4	48.7 ± 10.0
Neutrophils, ×10⁶/mL	0.9 ± 0.6	1.0 ± 0.3	1.2 ± 0.5	0.6 ± 0.2	0.9 ± 0.2	1.0 ± 0.3†
Lymphocytes, ×10⁶/mL	7.3 ± 1.7	9.7 ± 1.6*	9.7 ± 1.3*	2.9 ± 1.5	5.2 ± 1.6	4.4 ± 1.9
Monocytes, ×10⁶/mL	0.2 ± 0.1	0.2 ± 0.1	0.2 ± 0.1	0.1 ± 0.0	0.1 ± 0.0	0.2 ± 0.0
Eosinophils, ×10⁶/mL	0.2 ± 0.1	0.2 ± 0.1	0.2 ± 0.1	0.2 ± 0.0	0.2 ± 0.0	0.2 ± 0.1

Data represent mean ± SD, 1-way ANOVA with Bonferroni multiple comparison test. Mcl-1^fl/fl and Mcl-1^Pf4Δ/Pf4Δ mice were compared to Mcl-1^+/+ mice according to treatment groups.

MPV indicates mean platelet volume; and PDW, platelet distribution width.

P < .0001.

†

P < .005.

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