Clinical characteristics of ITP patient cohort: intracellular B-cell IL-10 production assay
| Intracellular B-cell IL-10 production assay, patient no. . | Sex . | Age, y . | Treatment . | Platelet count, 109/L . |
|---|---|---|---|---|
| Platelet count < 50 × 109/L (only patients 13, 14, and 20 were splenectomized) | ||||
| Same as 31 | M | 37 | No treatment | 5 |
| Same as 42 | M | 69 | No treatment | 11 |
| Same as 7 | F | 29 | On TPO agent | 12 |
| Same as 13 | M | 54 | On TPO agent | 4 |
| Same as 14 | M | 16 | On TPO agent | 13 |
| Same as 20 | M | 45 | On TPO agent | 40 |
| 27 | M | 14 | On TPO agent | 21 |
| Platelet count > 50 × 109/L (patients 18, 23, and 28 were splenectomized) | ||||
| 28 | F | 31 | No treatment | 112 |
| 29 | F | 55 | Partially in remission | 54 |
| 30 | F | 21 | In remission | 165 |
| Same as 184 | M | 81 | On TPO agent | 52 |
| Same as 236 | F | 69 | On TPO agent | 123 |
| Intracellular B-cell IL-10 production assay, patient no. . | Sex . | Age, y . | Treatment . | Platelet count, 109/L . |
|---|---|---|---|---|
| Platelet count < 50 × 109/L (only patients 13, 14, and 20 were splenectomized) | ||||
| Same as 31 | M | 37 | No treatment | 5 |
| Same as 42 | M | 69 | No treatment | 11 |
| Same as 7 | F | 29 | On TPO agent | 12 |
| Same as 13 | M | 54 | On TPO agent | 4 |
| Same as 14 | M | 16 | On TPO agent | 13 |
| Same as 20 | M | 45 | On TPO agent | 40 |
| 27 | M | 14 | On TPO agent | 21 |
| Platelet count > 50 × 109/L (patients 18, 23, and 28 were splenectomized) | ||||
| 28 | F | 31 | No treatment | 112 |
| 29 | F | 55 | Partially in remission | 54 |
| 30 | F | 21 | In remission | 165 |
| Same as 184 | M | 81 | On TPO agent | 52 |
| Same as 236 | F | 69 | On TPO agent | 123 |
Patients are grouped according to platelet counts of below 50 × 109/L or above 50 × 109/L. In many cases, the same patient's blood was drawn for the study on more than one visit and this has been indicated by referring to such patients as “same as no.” Some patients were also analyzed for B-cell surface phenotypic expression as well as functional studies on the same visit and they are indicated by the number followed by a numerical superscript. Patients' age and sex, as well as their platelet counts and the ITP treatment type on the day of the blood draw, are indicated. The exact B-cell subset frequencies for each patient are shown in supplemental Table 1.