BC diagnostics
. | Test rationale . |
---|---|
Test at diagnosis of BC | |
CBC with differential and bone marrow | Proportions of blasts, promyelocytes, and basophils? |
Flow cytometry and/or cytochemistry | Myeloid or lymphoid phenotype? |
Cytogenetics | Clonal evolution? |
Molecular genetics | Mutation profile? Choice of TKI |
Donor search (if applicable) | Allo-SCT |
Follow-up under therapy | |
Blood count and differential | Return to CP? |
Bone marrow and cytogenetics | Ascertainment of second CP |
Molecular genetics | Monitoring of BCR-ABL transcript levels under TKI and after allo-SCT |
In lymphoid BC: CSF cytology | Intrathecal instillation for neuroprophylaxis |
. | Test rationale . |
---|---|
Test at diagnosis of BC | |
CBC with differential and bone marrow | Proportions of blasts, promyelocytes, and basophils? |
Flow cytometry and/or cytochemistry | Myeloid or lymphoid phenotype? |
Cytogenetics | Clonal evolution? |
Molecular genetics | Mutation profile? Choice of TKI |
Donor search (if applicable) | Allo-SCT |
Follow-up under therapy | |
Blood count and differential | Return to CP? |
Bone marrow and cytogenetics | Ascertainment of second CP |
Molecular genetics | Monitoring of BCR-ABL transcript levels under TKI and after allo-SCT |
In lymphoid BC: CSF cytology | Intrathecal instillation for neuroprophylaxis |
BC indicates blast crisis; CP, chronic phase; CSF, cerebrospinal fluid; CBC, complete blood count; and TKI, tyrosine kinase inhibitor.