Table 1

BC diagnostics

Test rationale
Test at diagnosis of BC  
    CBC with differential and bone marrow Proportions of blasts, promyelocytes, and basophils? 
    Flow cytometry and/or cytochemistry Myeloid or lymphoid phenotype? 
    Cytogenetics Clonal evolution? 
    Molecular genetics Mutation profile? Choice of TKI 
    Donor search (if applicable) Allo-SCT 
Follow-up under therapy  
    Blood count and differential Return to CP? 
    Bone marrow and cytogenetics Ascertainment of second CP 
    Molecular genetics Monitoring of BCR-ABL transcript levels under TKI and after allo-SCT 
    In lymphoid BC: CSF cytology Intrathecal instillation for neuroprophylaxis 
Test rationale
Test at diagnosis of BC  
    CBC with differential and bone marrow Proportions of blasts, promyelocytes, and basophils? 
    Flow cytometry and/or cytochemistry Myeloid or lymphoid phenotype? 
    Cytogenetics Clonal evolution? 
    Molecular genetics Mutation profile? Choice of TKI 
    Donor search (if applicable) Allo-SCT 
Follow-up under therapy  
    Blood count and differential Return to CP? 
    Bone marrow and cytogenetics Ascertainment of second CP 
    Molecular genetics Monitoring of BCR-ABL transcript levels under TKI and after allo-SCT 
    In lymphoid BC: CSF cytology Intrathecal instillation for neuroprophylaxis 

BC indicates blast crisis; CP, chronic phase; CSF, cerebrospinal fluid; CBC, complete blood count; and TKI, tyrosine kinase inhibitor.

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