BC diagnostics
| . | Test rationale . |
|---|---|
| Test at diagnosis of BC | |
| CBC with differential and bone marrow | Proportions of blasts, promyelocytes, and basophils? |
| Flow cytometry and/or cytochemistry | Myeloid or lymphoid phenotype? |
| Cytogenetics | Clonal evolution? |
| Molecular genetics | Mutation profile? Choice of TKI |
| Donor search (if applicable) | Allo-SCT |
| Follow-up under therapy | |
| Blood count and differential | Return to CP? |
| Bone marrow and cytogenetics | Ascertainment of second CP |
| Molecular genetics | Monitoring of BCR-ABL transcript levels under TKI and after allo-SCT |
| In lymphoid BC: CSF cytology | Intrathecal instillation for neuroprophylaxis |
| . | Test rationale . |
|---|---|
| Test at diagnosis of BC | |
| CBC with differential and bone marrow | Proportions of blasts, promyelocytes, and basophils? |
| Flow cytometry and/or cytochemistry | Myeloid or lymphoid phenotype? |
| Cytogenetics | Clonal evolution? |
| Molecular genetics | Mutation profile? Choice of TKI |
| Donor search (if applicable) | Allo-SCT |
| Follow-up under therapy | |
| Blood count and differential | Return to CP? |
| Bone marrow and cytogenetics | Ascertainment of second CP |
| Molecular genetics | Monitoring of BCR-ABL transcript levels under TKI and after allo-SCT |
| In lymphoid BC: CSF cytology | Intrathecal instillation for neuroprophylaxis |
BC indicates blast crisis; CP, chronic phase; CSF, cerebrospinal fluid; CBC, complete blood count; and TKI, tyrosine kinase inhibitor.