Association of NHL with tertiles of serum carotenoids
| Biomarker . | T1 . | T2 . | T3 . | Ptrend* . |
|---|---|---|---|---|
| Total carotenoids, ng/mL | ||||
| Tertile cut-points | < 1040.49 | 1040.49-1550.33 | ≥ 1550.34 | |
| Cases/controls | 109/159 | 76/195 | 86/184 | |
| OR (95% CI) | 1.00 | 0.56 (0.38-0.81) | 0.66 (0.46-0.96) | .02 |
| α-carotene, ng/mL | ||||
| Tertile cut-points | < 38.53 | 38.53-68.75 | ≥ 68.76 | |
| Cases/controls | 102/169 | 80/190 | 89/179 | |
| OR (95% CI) | 1.00 | 0.70 (0.49-1.00) | 0.81 (0.56-1.17) | .34 |
| β-carotene, ng/mL | ||||
| Tertile cut-points | < 167.52 | 167.52-353.05 | ≥ 353.06 | |
| Cases/controls | 101/164 | 79/188 | 91/186 | |
| OR (95% CI) | 1.00 | 0.67 (0.47-0.97) | 0.77 (0.53-1.12) | .06 |
| Lycopene, ng/mL | ||||
| Tertile cut-points | < 345.70 | 345.70-510.43 | ≥ 510.44 | |
| Cases/controls | 109/155 | 87/184 | 75/199 | |
| OR (95% CI) | 1.00 | 0.68 (0.48-0.97) | 0.54 (0.38-0.78) | .003 |
| Dihydrolycopene, ng/mL | ||||
| Tertile cut-points | < 85.14 | 85.14-122.47 | ≥ 122.48 | |
| Cases/controls | 110/155 | 88/182 | 73/201 | |
| OR (95% CI) | 1.00 | 0.69 (0.48-0.98) | 0.51 (0.35-0.73) | .007 |
| trans-lutein, ng/mL | ||||
| Tertile cut-points | < 84.33 | 84.33-122.36 | ≥ 122.37 | |
| Cases/controls | 95/173 | 98/174 | 78/191 | |
| OR (95% CI) | 1.00 | 1.03 (0.73-1.46) | 0.71 (0.48-1.04) | .08 |
| α-cryptoxanthin, ng/mL | ||||
| Tertile cut-points | < 27.16 | 27.16-37.72 | ≥ 37.73 | |
| Cases/controls | 112/158 | 79/187 | 80/193 | |
| OR (95% CI) | 1.00 | 0.57 (0.40-0.82) | 0.53 (0.36-0.78) | .003 |
| β-cryptoxanthin, ng/mL | ||||
| Tertile cut-points | < 126.45 | 126.45-232.90 | ≥ 232.91 | |
| Cases/controls | 90/181 | 100/169 | 81/188 | |
| OR (95% CI) | 1.00 | 1.18 (0.83-1.68) | 0.84 (0.57-1.24) | .55 |
| trans-zeaxanthin, ng/mL | ||||
| Tertile cut-points | < 16.92 | 16.92-24.05 | ≥ 24.06 | |
| Cases/controls | 88/180 | 96/177 | 87/181 | |
| OR (95% CI) | 1.00 | 1.12 (0.78-1.60) | 0.98 (0.68-1.43) | .66 |
| Retinol, ng/mL | ||||
| Tertile cut-points | < 587.75 | 587.75-740.43 | ≥ 740.44 | |
| Cases/controls | 98/176 | 84/186 | 89/176 | |
| OR (95% CI) | 1.00 | 0.81 (0.56-1.16) | 0.90 (0.61-1.33) | .04 |
| Biomarker . | T1 . | T2 . | T3 . | Ptrend* . |
|---|---|---|---|---|
| Total carotenoids, ng/mL | ||||
| Tertile cut-points | < 1040.49 | 1040.49-1550.33 | ≥ 1550.34 | |
| Cases/controls | 109/159 | 76/195 | 86/184 | |
| OR (95% CI) | 1.00 | 0.56 (0.38-0.81) | 0.66 (0.46-0.96) | .02 |
| α-carotene, ng/mL | ||||
| Tertile cut-points | < 38.53 | 38.53-68.75 | ≥ 68.76 | |
| Cases/controls | 102/169 | 80/190 | 89/179 | |
| OR (95% CI) | 1.00 | 0.70 (0.49-1.00) | 0.81 (0.56-1.17) | .34 |
| β-carotene, ng/mL | ||||
| Tertile cut-points | < 167.52 | 167.52-353.05 | ≥ 353.06 | |
| Cases/controls | 101/164 | 79/188 | 91/186 | |
| OR (95% CI) | 1.00 | 0.67 (0.47-0.97) | 0.77 (0.53-1.12) | .06 |
| Lycopene, ng/mL | ||||
| Tertile cut-points | < 345.70 | 345.70-510.43 | ≥ 510.44 | |
| Cases/controls | 109/155 | 87/184 | 75/199 | |
| OR (95% CI) | 1.00 | 0.68 (0.48-0.97) | 0.54 (0.38-0.78) | .003 |
| Dihydrolycopene, ng/mL | ||||
| Tertile cut-points | < 85.14 | 85.14-122.47 | ≥ 122.48 | |
| Cases/controls | 110/155 | 88/182 | 73/201 | |
| OR (95% CI) | 1.00 | 0.69 (0.48-0.98) | 0.51 (0.35-0.73) | .007 |
| trans-lutein, ng/mL | ||||
| Tertile cut-points | < 84.33 | 84.33-122.36 | ≥ 122.37 | |
| Cases/controls | 95/173 | 98/174 | 78/191 | |
| OR (95% CI) | 1.00 | 1.03 (0.73-1.46) | 0.71 (0.48-1.04) | .08 |
| α-cryptoxanthin, ng/mL | ||||
| Tertile cut-points | < 27.16 | 27.16-37.72 | ≥ 37.73 | |
| Cases/controls | 112/158 | 79/187 | 80/193 | |
| OR (95% CI) | 1.00 | 0.57 (0.40-0.82) | 0.53 (0.36-0.78) | .003 |
| β-cryptoxanthin, ng/mL | ||||
| Tertile cut-points | < 126.45 | 126.45-232.90 | ≥ 232.91 | |
| Cases/controls | 90/181 | 100/169 | 81/188 | |
| OR (95% CI) | 1.00 | 1.18 (0.83-1.68) | 0.84 (0.57-1.24) | .55 |
| trans-zeaxanthin, ng/mL | ||||
| Tertile cut-points | < 16.92 | 16.92-24.05 | ≥ 24.06 | |
| Cases/controls | 88/180 | 96/177 | 87/181 | |
| OR (95% CI) | 1.00 | 1.12 (0.78-1.60) | 0.98 (0.68-1.43) | .66 |
| Retinol, ng/mL | ||||
| Tertile cut-points | < 587.75 | 587.75-740.43 | ≥ 740.44 | |
| Cases/controls | 98/176 | 84/186 | 89/176 | |
| OR (95% CI) | 1.00 | 0.81 (0.56-1.16) | 0.90 (0.61-1.33) | .04 |
ORs and 95% CI estimated from conditional logistic regression with matched sets as strata. Cases and controls were matched on sex, age (± 1 year), location (Hawaii or California), ethnicity, date of blood draw (± 1 year), time of blood draw (± 2 hours), and hours fasting before blood draw (< 6, 6 to < 8, 8 to < 10, ≥ 10).
P value for the Wald χ2 test of Ho: β = 0 when modeling the natural log–transformed continuous variable.