Sequence and clonotype analysis of mice with GVHD-associated autoimmunity
| . | Experiment 1 . | Experiment 2 . | Experiment 3 . | Total . |
|---|---|---|---|---|
| Total no. of sequences | 865 | 610 | 561 | 2036 |
| Total no. of clonotypes | 51 | 29 | 94 | 174 |
| No. of overlapping sequences (% of total)* | 453 (52%) | 574 (94%) | 334 (60%) | 1361 (67%) |
| No. of overlapping clonotypes (% of total)† | 6 (12%) | 9 (31%) | 10 (11%) | 25 (14%) |
| . | Experiment 1 . | Experiment 2 . | Experiment 3 . | Total . |
|---|---|---|---|---|
| Total no. of sequences | 865 | 610 | 561 | 2036 |
| Total no. of clonotypes | 51 | 29 | 94 | 174 |
| No. of overlapping sequences (% of total)* | 453 (52%) | 574 (94%) | 334 (60%) | 1361 (67%) |
| No. of overlapping clonotypes (% of total)† | 6 (12%) | 9 (31%) | 10 (11%) | 25 (14%) |
Data represent the overall number of sequences and clonotypes from dominant focused peaks that were obtained from the colons of animals. Data are derived from 3 independent experiments in which mice received either unseparated spleen cells adjusted to yield a fixed αβ T-cell dose (experiments 1 and 2) or purified CD4+ T cells (experiment 3).
Number of sequences that were observed in more than 1 mouse within a given experiment.
Number of clonotypes that were observed in more than 1 mouse within a given experiment.