Table 2

Activity of radiation or alkylator-based therapies for the treatment of POEMS syndrome

RegimenOutcome
Radiation9,43-46  ≥ 50% of patients have significant clinical improvement 
Mel-Dex38  81% hematologic response rate; 100% with some neurologic improvement 
Corticosteroids ≥ 15% of patients have significant clinical improvement 
ASCT 100% of surviving patients have significant clinical improvement 
RegimenOutcome
Radiation9,43-46  ≥ 50% of patients have significant clinical improvement 
Mel-Dex38  81% hematologic response rate; 100% with some neurologic improvement 
Corticosteroids ≥ 15% of patients have significant clinical improvement 
ASCT 100% of surviving patients have significant clinical improvement 

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