Summary of individual parameter estimates: median values and 25th and 75th percentiles
| Parameter . | Children (age 1-6 years; N = 52) . | Adolescents/adults (age 10-65; N = 184) . | ||||
|---|---|---|---|---|---|---|
| Population PK model . | Individual PK analysis13 . | Difference* . | Population PK model . | Individual PK analysis13 . | Difference* . | |
| Incremental recovery, (IU/dL per IU/kg) | 2.39† (2.18-2.64) | 1.84 (1.64-2.02) | 0.57 (0.53-0.63) | 2.50† (2.19-2.83) | 2.43 (2.10-2.80) | 0.08 (−0.05-0.19) |
| Clearance, mL/(kg × hr) | 4.72 (3.83-5.53) | 4.34 (3.39-5.46) | 0.29 (0.00-0.49) | 3.34 (2.59-4.21) | 3.31 (2.69-4.22) | 0.03 (−0.21-0.22) |
| Volume of distribution (Vss), L/kg | 0.059 (0.055-0.063) | 0.050 (0.045-0.058) | 0.008 (0.005-0.010) | 0.053 (0.047-0.059) | 0.048 (0.041-0.055) | 0.005 (0.002-0.008) |
| Terminal half-life, hours | 9.2 (8.0-10.6) | 9.4 (8.1-10.8) | −0.08 (−1.02-0.42) | 12.2 (10.5-13.9) | 11.1 (9.7-12.6) | 0.85 (−0.18-2.25) |
| Parameter . | Children (age 1-6 years; N = 52) . | Adolescents/adults (age 10-65; N = 184) . | ||||
|---|---|---|---|---|---|---|
| Population PK model . | Individual PK analysis13 . | Difference* . | Population PK model . | Individual PK analysis13 . | Difference* . | |
| Incremental recovery, (IU/dL per IU/kg) | 2.39† (2.18-2.64) | 1.84 (1.64-2.02) | 0.57 (0.53-0.63) | 2.50† (2.19-2.83) | 2.43 (2.10-2.80) | 0.08 (−0.05-0.19) |
| Clearance, mL/(kg × hr) | 4.72 (3.83-5.53) | 4.34 (3.39-5.46) | 0.29 (0.00-0.49) | 3.34 (2.59-4.21) | 3.31 (2.69-4.22) | 0.03 (−0.21-0.22) |
| Volume of distribution (Vss), L/kg | 0.059 (0.055-0.063) | 0.050 (0.045-0.058) | 0.008 (0.005-0.010) | 0.053 (0.047-0.059) | 0.048 (0.041-0.055) | 0.005 (0.002-0.008) |
| Terminal half-life, hours | 9.2 (8.0-10.6) | 9.4 (8.1-10.8) | −0.08 (−1.02-0.42) | 12.2 (10.5-13.9) | 11.1 (9.7-12.6) | 0.85 (−0.18-2.25) |