Parameter estimates for the final model, based on data from all patients
| Parameter . | Full sampling* . | Reduced sampling† . | ||
|---|---|---|---|---|
| Mean . | % RSE . | Mean . | % RSE . | |
| Structural model parameters | ||||
| Clearance (CL), mL/h‡ | 193 | 2.7 | 188 | 2.8 |
| Volume of central compartment (V1), L§ | 2.22 | 1.9 | 2.26 | 2.2 |
| Intercompartmental clearance (Q), mL/h | 147 | 8.6 | 137 | 14 |
| Volume of peripheral compartment (V2), L§ | 0.73 | 7.8 | 0.75 | 7.9 |
| Interindividual variability parameters | ||||
| Clearance (% CV) | 30 | 15 | 30 | 15 |
| Volume of central compartment (% CV) | 21 | 14 | 23 | 14 |
| Correlation between CL and V1 | 0.45 | 22 | 0.49 | 22 |
| Residual variability parameters | ||||
| Additive residual error (SD), IU/dL | 8.9 | 3.5 | 7.1 | 5.7 |
| Covariate parameters | ||||
| Allometric exponent for CL | 0.80 | 5.9 | 0.75 | 6.3 |
| Allometric exponent for V1 | 0.95 | 2.8 | 0.97 | 2.9 |
| Allometric exponent for V2 | 0.76 | 18 | 0.82 | 14 |
| CL (% change with age different from 22 y) | −0.45 | 41 | −0.13 | 152 |
| Parameter . | Full sampling* . | Reduced sampling† . | ||
|---|---|---|---|---|
| Mean . | % RSE . | Mean . | % RSE . | |
| Structural model parameters | ||||
| Clearance (CL), mL/h‡ | 193 | 2.7 | 188 | 2.8 |
| Volume of central compartment (V1), L§ | 2.22 | 1.9 | 2.26 | 2.2 |
| Intercompartmental clearance (Q), mL/h | 147 | 8.6 | 137 | 14 |
| Volume of peripheral compartment (V2), L§ | 0.73 | 7.8 | 0.75 | 7.9 |
| Interindividual variability parameters | ||||
| Clearance (% CV) | 30 | 15 | 30 | 15 |
| Volume of central compartment (% CV) | 21 | 14 | 23 | 14 |
| Correlation between CL and V1 | 0.45 | 22 | 0.49 | 22 |
| Residual variability parameters | ||||
| Additive residual error (SD), IU/dL | 8.9 | 3.5 | 7.1 | 5.7 |
| Covariate parameters | ||||
| Allometric exponent for CL | 0.80 | 5.9 | 0.75 | 6.3 |
| Allometric exponent for V1 | 0.95 | 2.8 | 0.97 | 2.9 |
| Allometric exponent for V2 | 0.76 | 18 | 0.82 | 14 |
| CL (% change with age different from 22 y) | −0.45 | 41 | −0.13 | 152 |
RSE indicates relative standard error; and CV, coefficient of variation.
Four postinfusion samples in children, 10 in adolescents/adults.
Four postinfusion samples in all patients.
Typical value for a person with median body weight (56 kg) and age (22 y).
Typical value for a person with median body weight (56 kg).