Table 2 Summary of model building steps,... | American Society of Hematology

Table 2

Summary of model building steps, with the −2LL values

Model	Characteristics	No. of parameters*	−2LL
Structural model
1	1 compartment	5	17 215
2	1 compartment with IIV† allowed for V1 and CL	8	17 053
3	2 compartments	8	15 705
4	2 compartments with IIV† allowed for V1 and CL	11	15 237
Interoccasion variance (added to model 4)
5	Allowed for CL	12	15 243
6	Allowed for V1	12	15 264
Covariate (added to model 4)
7	Age as covariate on CL	12	15 232
8	Age as covariate on V1	12	15 237

Model	Characteristics	No. of parameters*	−2LL
Structural model
1	1 compartment	5	17 215
2	1 compartment with IIV† allowed for V1 and CL	8	17 053
3	2 compartments	8	15 705
4	2 compartments with IIV† allowed for V1 and CL	11	15 237
Interoccasion variance (added to model 4)
5	Allowed for CL	12	15 243
6	Allowed for V1	12	15 264
Covariate (added to model 4)
7	Age as covariate on CL	12	15 232
8	Age as covariate on V1	12	15 237

A lower value indicates a better model (a change of 3.85 units is significant at P = .05); thus, model 7 was the final one.

Number of estimated parameters in the model.

Interindividual variance.