Table 6

Multivariable Cox model for overall survival (stratified by trials for younger vs elderly patients)

FactorHazard ratio95% CIP
s-/t-AML 1.28 1.07-1.53 .007 
Age, difference of 10 y 1.20 1.10-1.31 < .0001 
Log10 of WBC 1.33 1.19-1.50 < .0001 
Log10 of platelets 0.81 0.69-0.87 .02 
Monosomal karyotype* 1.60 1.30-1.97 < .0001 
Complex karyotype† 1.57 1.27-1.94 < .0001 
t(6;9) 1.34 0.73-2.44 .35 
t(9;11) 0.79 0.51-1.23 .29 
t(v;11)(v;q23) 1.36 0.95-1.97 .10 
inv(3) or t(3;3) 1.99 1.34-2.96 .0007 
NPM1 mutation 0.59 0.41-0.85 .006 
FLT3-ITD 1.45 1.12-1.87 .004 
FactorHazard ratio95% CIP
s-/t-AML 1.28 1.07-1.53 .007 
Age, difference of 10 y 1.20 1.10-1.31 < .0001 
Log10 of WBC 1.33 1.19-1.50 < .0001 
Log10 of platelets 0.81 0.69-0.87 .02 
Monosomal karyotype* 1.60 1.30-1.97 < .0001 
Complex karyotype† 1.57 1.27-1.94 < .0001 
t(6;9) 1.34 0.73-2.44 .35 
t(9;11) 0.79 0.51-1.23 .29 
t(v;11)(v;q23) 1.36 0.95-1.97 .10 
inv(3) or t(3;3) 1.99 1.34-2.96 .0007 
NPM1 mutation 0.59 0.41-0.85 .006 
FLT3-ITD 1.45 1.12-1.87 .004 

CI indicates confidence interval; ITD, internal tandem duplication; s-AML, secondary acute myeloid leukemia; t-AML, therapy-related acute myeloid leukemia; and WBC, white blood count.

*

According to Breems et al.7 

†

According to Döhner et al.6 

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