Table 5

Multivariable logistic regression analysis on response to induction therapy

FactorOdds ratio95% CIP
s-/t-AML 0.65 0.46-0.92 .02 
Age, difference of 10 y 0.67 0.60-0.74 < .0001 
Log10 of WBC 0.75 0.61-0.91 .007 
Log10 of platelets 1.18 0.84-1.61 .35 
Monosomal karyotype* 0.58 0.39-0.86 .007 
Complex karyotype† 0.64 0.43-0.94 .02 
t(6;9) 1.27 0.45-3.62 .65 
t(9;11) 1.67 0.86-3.25 .13 
t(v;11)(v;q23) 0.81 0.45-1.45 .47 
inv(3) or t(3;3) 0.16 0.06-0.39 .0001 
NPM1 mutation 2.73 1.42-5.27 .003 
FLT3-ITD 0.69 0.43-1.10 .12 
FactorOdds ratio95% CIP
s-/t-AML 0.65 0.46-0.92 .02 
Age, difference of 10 y 0.67 0.60-0.74 < .0001 
Log10 of WBC 0.75 0.61-0.91 .007 
Log10 of platelets 1.18 0.84-1.61 .35 
Monosomal karyotype* 0.58 0.39-0.86 .007 
Complex karyotype† 0.64 0.43-0.94 .02 
t(6;9) 1.27 0.45-3.62 .65 
t(9;11) 1.67 0.86-3.25 .13 
t(v;11)(v;q23) 0.81 0.45-1.45 .47 
inv(3) or t(3;3) 0.16 0.06-0.39 .0001 
NPM1 mutation 2.73 1.42-5.27 .003 
FLT3-ITD 0.69 0.43-1.10 .12 

CI indicates confidence interval; ITD, internal tandem duplication; s-AML, secondary acute myeloid leukemia; t-AML, therapy-related acute myeloid leukemia; and WBC, white blood count.

*

According to Breems et al.7 

†

According to Döhner et al.6 

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