Table 3 Genetic characteristics... | American Society of Hematology

Table 3

Genetic characteristics according to complex and monosomal karyotype (n = 1058)

Characteristics/cytogenetic abnormalities	Other, n (%), n = 646	MK⁺, n (%), n = 77	CK⁺, n (%), n = 93	MK⁺CK⁺, n (%), n = 242	P
t(9;11)	55 (9)	–	–	–	†
t(v;11)(v;q23)*	52 (8)	7 (9)	–	–	†
t(6;9)*	16 (3)	3 (4)	–	–	†
inv(3) or t(3;3)	11 (2)	34 (44)	–	–	†
−5 or 5q−	34 (5)	8 (10)	27 (29)	166 (69)	< .0001
−7	41 (6)	57 (74)	1 (1)	85 (35)	< .0001
7q−	41 (6)	7 (9)	13 (14)	47 (19)	< .0001
+8 or +8q	164 (25)	3 (4)	41 (44)	42 (17)	< .0001
+11 or +11q	23 (4)	0	14 (15)	20 (8)	< .0001
abnl(12p)	30 (5)	5 (7)	15 (16)	72 (30)	< .0001
+13 or +13q	23 (4)	0	10 (11)	10 (4)	.005
abnl(17p)	9 (1)	7 (9)	9 (10)	123 (51)	< .0001
−18 or 18q−	1 (0.2)	6 (8)	2 (2)	55 (23)	< .0001
−20 or 20q−	25 (4)	7 (9)	7 (8)	54 (22)	< .0001
+21 or +21q	31 (5)	1 (1)	18 (19)	22 (9)	< .0001
+22 or +22q	5 (1)	0	13 (14)	13 (5)	< .0001

Characteristics/cytogenetic abnormalities	Other, n (%), n = 646	MK⁺, n (%), n = 77	CK⁺, n (%), n = 93	MK⁺CK⁺, n (%), n = 242	P
t(9;11)	55 (9)	–	–	–	†
t(v;11)(v;q23)*	52 (8)	7 (9)	–	–	†
t(6;9)*	16 (3)	3 (4)	–	–	†
inv(3) or t(3;3)	11 (2)	34 (44)	–	–	†
−5 or 5q−	34 (5)	8 (10)	27 (29)	166 (69)	< .0001
−7	41 (6)	57 (74)	1 (1)	85 (35)	< .0001
7q−	41 (6)	7 (9)	13 (14)	47 (19)	< .0001
+8 or +8q	164 (25)	3 (4)	41 (44)	42 (17)	< .0001
+11 or +11q	23 (4)	0	14 (15)	20 (8)	< .0001
abnl(12p)	30 (5)	5 (7)	15 (16)	72 (30)	< .0001
+13 or +13q	23 (4)	0	10 (11)	10 (4)	.005
abnl(17p)	9 (1)	7 (9)	9 (10)	123 (51)	< .0001
−18 or 18q−	1 (0.2)	6 (8)	2 (2)	55 (23)	< .0001
−20 or 20q−	25 (4)	7 (9)	7 (8)	54 (22)	< .0001
+21 or +21q	31 (5)	1 (1)	18 (19)	22 (9)	< .0001
+22 or +22q	5 (1)	0	13 (14)	13 (5)	< .0001

CK indicates complex karyotype; MK, monosomal karyotype; and –, not applicable. Percentages may not add to 100 because of rounding.

One case exhibited a t(6;9) and t(v;11)(v;q23) concurrently.

Per definition no CK possible according to Swerdlow et al³ and Döhner et al.⁶